Cognitive-motor dual-task training improves dynamic stability during straight and curved gait in patients with multiple sclerosis: a randomized controlled trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37997324/
Cognitive-motor DT implemented into the neurorehabilitation conventional program could be a useful strategy for gait and balance rehabilitation.
This study demonstrates that cognitive-motor dual-task training (DT) improves dynamic gait quality, stability, symmetry, and smoothness in people with multiple sclerosis (PwMS), supporting its effectiveness in neurorehabilitation.
Bioavailability as Proof to Authorize the Clinical Testing of Neurodegenerative Drugs-Protocols and Advice for the FDA to Meet the ALS Act Vision - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39337696/
Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD...
The study suggests that the FDA should focus on improving drug bioavailability across the blood-brain barrier for neurodegenerative diseases, requiring proof of brain entry for IND approval and reconsidering biomarker reliance.
Fluid biomarkers in multiple sclerosis: from current to future applications - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39444698/
Multiple sclerosis (MS) is an immune-mediated inflammatory and degenerative disorder of the central nervous system (CNS) with heterogeneous clinical manifestations. In the last decade, the landscape of cerebrospinal fluid (CSF)...
This article explores cerebrospinal fluid (CSF) and blood biomarkers for multiple sclerosis (MS), highlighting their role in diagnosis, prognosis, treatment monitoring, and personalized management, while addressing real-world challenges.
Factors Contributing to the Development of Neuropsychiatric Manifestations in Persons With Multiple Sclerosis: A Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39246867/
Multiple sclerosis (MS) is the most common chronic demyelinating disease affecting the central nervous system (CNS) and is distinguished by neuroinflammation and neurodegeneration. It has four categories based on clinical...
This systematic review explores factors influencing neuropsychiatric manifestations in multiple sclerosis, including brain changes, immune mechanisms, socioeconomic, and individual factors, highlighting the need for further research to improve patient outcomes.
A case report and review of rheumatoid arthritis co-occurring with tuberous sclerosis complex, a rare occurrence - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39391300/
Rheumatoid arthritis (RA) is a common autoimmune disease. Tuberous sclerosis complex(TSC) is a rare autosomal dominant disorder. We report a case of RA with TSC. The patient was a 46-year-old...
A 46-year-old woman with RA and persistent cough was diagnosed with TSC after further evaluation revealed lymphangioleiomyomatosis, angiomyolipomas, subependymal nodules, and other TSC features. Everolimus improved her symptoms.