Unleashing the power of anti-CD20 immunotherapy: Mitigating multiple sclerosis risk in Epstein-Barr virus latent infections - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38085006/
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative connective tissue disease affecting the central nervous system (CNS). Recently, there has been a dramatic improvement in several vital concepts...
Anti-CD20 monoclonal antibodies show promise in treating multiple sclerosis by targeting EBV-associated memory B cells, despite potential adverse effects that can be managed with careful planning.
Dermatological Neoplastic Diseases Complicating Treatment with Monoclonal Antibodies for Multiple Sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39274345/
Background: Over the past 20 years, the treatment scenario of multiple sclerosis (MS) has radically changed, and an ever-increasing number of disease-modifying treatments has emerged. Among high-efficacy treatment agents, monoclonal...
This review examines cutaneous malignancies in multiple sclerosis patients receiving monoclonal antibodies, assessing the need for dermatological follow-ups due to unclear cancer risk associations.
What's new in NMOSD and MOGAD? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39277477/
In this mini-review, we focus on novelties in the field of neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). We first describe the proposed criteria...
This review explores recent advancements in NMOSD and MOGAD, focusing on diagnostic criteria, clinical features of double seronegative cases, and future treatment.
Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38795640/
Neuroimmune and neurodegenerative ailments impose a substantial societal burden. Neuroimmune disorders involve the intricate regulatory interactions between the immune system and the central nervous system. Prominent examples of neuroimmune disorders...
Ferroptosis, characterized by lipid peroxidation and iron overload, affects neuroimmune and neurodegenerative diseases. This review covers its mechanisms, impacts on immune and neural cells, and therapeutic potential.
Neuromyelitis optica spectrum disorder: Exploring the diverse clinical manifestations and the need for further exploration - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39135307/
It is essential to acknowledge the complex and varied clinical manifestations of NMOSD to enhance diagnosis, treatment, and patient results. By enhancing our comprehension of the fundamental processes and investigating...
NMOSD presents with diverse symptoms beyond optic neuritis and transverse myelitis, including unusual signs like muscle involvement and auditory impairment, highlighting the need for better understanding and targeted treatments.