Pharmacokinetics and Pharmacodynamics of Natalizumab 6-Week Dosing vs Continued 4-Week Dosing for Relapsing-Remitting Multiple Sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39393045/
ClinicalTrials.gov, NCT03689972; EudraCT, 2018-002145-11. Submitted 2018-09-27. First patient enrolled: 2018-12-26. https://clinicaltrials.gov/study/NCT03689972.
Extended-interval natalizumab dosing (Q6W) reduced PML risk while maintaining efficacy in most RRMS patients. Q6W decreased trough drug levels and α4-integrin saturation but did not consistently predict lesion or relapse activity.
Histoplasmosis in a fingolimod-treated patient: case report and scoping review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39052026/
Fingolimod is a sphingosine-1-phosphate receptor modulator used to treat multiple sclerosis. While fingolimod has been associated with an increased risk of cryptococcal meningitis, its correlation with other deep mycoses remains...
Fingolimod therapy for multiple sclerosis may increase the risk of disseminated histoplasmosis, especially in endemic regions. Prompt diagnosis, itraconazole treatment, and adjusting immunotherapy yield favorable outcomes.
Azathioprine for people with multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39651635/
Azathioprine has been proposed as an alternative treatment for MS when access to approved, on-label DMTs is limited, especially in resource-limited settings. The limited evidence available suggests that azathioprine may...
Azathioprine may modestly reduce relapse frequency in relapsing MS but with potential increased serious adverse events. Evidence on disability progression and long-term outcomes remains very uncertain, especially for progressive MS.
Surgical Interventions for the Management of Carpal Tunnel Syndrome: A Narrative Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38576667/
Carpal tunnel syndrome (CTS) is a severe condition that affects the hand, causing pain, numbness, paresthesia, and autonomic dysfunction caused by increased pressure, damage, and demyelination of the median nerve...
Carpal tunnel syndrome (CTS) is treated effectively with carpal tunnel release (CTR). While postoperative rehabilitation lacks strong evidence, CTR improves symptoms and satisfaction, with minimal complications reported in most studies.
Clinical and therapeutic challenges of smouldering multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38842128/
Innovative insights into the pathophysiology and clinical course warrant the need for a holistic approach to MS. The efforts of clinicians should be aimed at indicating subtle neurological deficits in...
Smouldering multiple sclerosis (MS) involves diffuse inflammation and remyelination failure, with progression independent of relapse. New neuroimaging markers and Bruton's tyrosine kinase inhibitors offer promising therapeutic options for disease management.