Kearns-Sayre Syndrome Masquerading as Myasthenia Gravis : Retinal Cases and Brief Reports
sthenia gravis (MG). Methods: Case report. Results: A 15-year-old male with a presumed diagnosis of MG presented with blurry vision, ophthalmoplegia, and ptosis. He was found to have a mitochondrial...
Conclusions: We report a case of KSS found to have a novel large-scale mtDNA deletion. The presence of a mitochondrial pigmentary retinopathy found on dilated examination led to reconsideration of the previous diagnosis of MG and ultimately led to the correct diagnosis of KSS.
What are the treatment options for myasthenia gravis if first-line agents fail?
Source : https://www.ccjm.org/content/90/2/81
If the patient with myasthenia gravis (MG) has been taking adequate doses of a first-line medication, typically pyridostigmine, for a sufficient duration but without significant efficacy, or has experienced substantial...
Conclusions: If the patient with myasthenia gravis (MG) has been taking adequate doses of a first-line medication, typically pyridostigmine, for a sufficient duration but without significant efficacy, or has experienced substantial adverse effects, it may be time to consider immunosuppressive therapy. In 5% to 20% of patients, there may be...
Treatment patterns in myasthenia gravis: a United States health claims analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36721910/
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Conclusions: Many patients experienced exacerbations and received rescue therapy despite treatment, suggesting current treatments may not provide adequate disease control for some patients, and additional treatment options should be explored.
Exploring the role of immune checkpoint inhibitors in the etiology of myasthenia gravis and Lambert-Eaton myasthenic syndrome: A systematic review
Source : https://www.frontiersin.org/articles/10.3389/fneur.2022.1004810/full
BackgroundWhile immune checkpoint inhibitors (ICIs) have been revolutionary in the treatment of cancer, their administration has been associated with a variety of immune-related adverse events (irAEs), including myasthenia gravis (MG),...
Conclusions: We argue that there is a need for future mechanistic, high quality, large-scale studies specifically investigating the possible etiological role of ICIs in MG/LEMS.
Effectiveness of early cycles of fast-acting treatment in generalised myasthenia gravis
Source : https://jnnp.bmj.com/content/early/2023/01/23/jnnp-2022-330519
Background Early fast-acting treatment (EFT) is the aggressive use of fast-acting therapies such as plasmapheresis, intravenous immunoglobulin and/or intravenous high-dose methylprednisolone (IVMP) from the early phases of treatment. EFT is...
Conclusions: Early cycles of intervention with EFT and early use of calcineurin inhibitors provides long-term benefits in terms of achieving therapeutic targets for generalised MG, regardless of clinical subtype.