Driving time-based identification of gaps in specialised care coverage: An example of neuroinflammatory diseases in Germany - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36762020/
An isochrone-based approach helps identify regions where specialised care is hard to reach, which might be especially troublesome in the case of an often disabled patient collective. Patient care could...
Conclusions: An isochrone-based approach helps identify regions where specialised care is hard to reach, which might be especially troublesome in the case of an often disabled patient collective. Patient care could be improved by focusing deployments of disease-specific DHTs on these areas.
Chronic mimics of myasthenia gravis: a retrospective case series - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36753801/
Myasthenia gravis often presents a diagnostic challenge and may be misdiagnosed, particularly in seronegative disease with active symptoms. We retrospectively evaluated 61 patients following the introduction of single fibre electromyography...
Conclusions: We found myasthenic mimics should be suspected in disease that is static and treatment refractory, and functional mimics in disease with frequent flares. Thorough neurophysiologic assessment is important, particularly when making a diagnosis of seronegative myasthenia gravis.
Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36754834/
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Conclusions: Our study suggests that AChR autoantibodies are produced by nonmalignant, polyclonal B cells The new anti-CD20 treatment obinutuzumab might be considered in effectively treating AChR MG.
Complement Activation Profiles in Anti-AChR Positive Myasthenia Gravis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36752022/
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Conclusions: Markers indicative of complement activation are prominently increased in patients with AChR-Ab MG despite standard immunosuppressive therapies. Complement inhibition proximal to C5 cleavage should be explored for its potential therapeutic benefits in AChR-Ab MG.
Myasthenia gravis: Frequently asked questions
Source : https://www.ccjm.org/content/90/2/103
Myasthenia gravis is a disorder of neuromuscular junction transmission, the result of antibodies against the post-synaptic aspect of the neuromuscular junction. Its clinical hallmark is fatigable weakness of skeletal muscles,...
Conclusions: This review uses a question-and-answer format to provide up-to-date, high-yield, clinically relevant information on myasthenia gravis.