The Usefulness of Swallowing Pressure Assessment in the Identification of Mild Pharyngeal Weakness of Myasthenia Gravis: A Case Report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36824579/
Despite the clinical impact of dysphagia in myasthenia gravis (MG), a standard protocol for diagnosing dysphagia reliably has not yet been established. High-resolution manometry (HRM) provides precise information on pharyngeal...
Conclusions: Swallowing pressure assessment during the EC test may be helpful in identifying mild bulbar symptoms in patients with MG.
COVID-19 and autoimmune diseases of the nervous system - an update - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36799522/
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Conclusions: Many reports have indicated that in patients with AIDs, the existence of the disease is not associated with a worse prognosis in the course of the viral infection. Patients in advanced stages of the disease, elderly patients, and those with comorbidities are at risk of more frequent hospitalisations and higher mortality in the...
Inflammation and autoimmune myasthenia gravis
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1110499/full
Myasthenia gravis (MG) is a neuromuscular autoimmune disorder characterized by chronic but intermittent fatigue of the eye- and general body muscles. Muscle weakness is caused primarily by the binding of...
Conclusions: This review briefly discusses some preclinical and clinical findings of inflammation associated with MG and current therapy approaches and suggest the potential of targeting important inflammatory marker(s) along with current monoclonal antibody or antibody fragment based targeted therapies directed to a variety of cell surface...
Single-cell mass cytometry on peripheral cells in Myasthenia Gravis identifies dysregulation of innate immune cells
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1083218/full
Myasthenia Gravis (MG) is a neurological autoimmune disease characterized by disabling muscle weaknesses due to anti-acetylcholine receptor (AChR) autoantibodies. To gain insight into immune dysregulation underlying early-onset AChR+ MG, we...
Conclusions: In MG, as for other B-cell mediated autoimmune diseases, dysregulations are well known for adaptive immune cells, such as B and T cells. Here, using single-cell mass cytometry, we unraveled unexpected dysregulations for innate immune cells. If these cells are known to be crucial for host defense, our results demonstrated that they...
Peripheral nervous system adverse events associated with immune checkpoint inhibitors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36800019/
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Conclusions: In our large cohort of ICI-treated patients, 2.17% developed PNS-irAEs. Compared to ir-neuropathies, ir-MG/myositis tend to occur earlier from ICI exposure and present a worse response to treatment and a higher mortality.