Different monoclonal antibodies and immunosuppressants administration in patients with neuromyelitis optica spectrum disorder: a Bayesian network meta-analysis - Journal of Neurology
Source : https://link.springer.com/article/10.1007/s00415-023-11641-1
Background A variety of novel monoclonal antibodies and immunosuppressant have been proved effective in treating Neuromyelitis Optica Spectrum Disorder (NMOSD). This network meta-analysis compared and ranked the efficacy and tolerability...
Conclusion: RTX and tocilizumab showed better efficacy than traditional immunosuppressants in reducing relapse. For safety, MMF and RTX had fewer AEs. However, studies with larger sample size on newly developed monoclonal antibodies are warranted in the future.
Ravulizumab pharmacokinetics and pharmacodynamics in patients with generalized myasthenia gravis - Journal of Neurology
Source : https://link.springer.com/article/10.1007/s00415-023-11617-1
Introduction The terminal complement C5 inhibitor ravulizumab has a long elimination half-life, allowing maintenance dosing every 8 weeks. In the 26-week, double-blind, randomized, placebo-controlled period (RCP) of the CHAMPION MG...
Conclusions: PK/PD evidence supports the use of ravulizumab every 8 weeks for immediate, complete, and sustained inhibition of terminal complement C5 in adults with AChR Ab+ gMG.
Conclusions/Relevance: While the landscape for treatment of generalized MG has expanded over recent years, there is still an unmet need for patients for whom multiple lines of treatment have failed. The introduction of neonatal Fc receptor antagonists such as efgartigimod alfa may have an immediate impact in patients for whom standard-of-care...
The determinants of expert opinion in the development of care pathways: insights from an exploratory cluster analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36869326/
These findings might indicate a poor ability of the expert to discriminate what is not appropriate from what is not complete. Also, the opinion of the expert might be influenced...
Conclusions: These findings might indicate a poor ability of the expert to discriminate what is not appropriate from what is not complete. Also, the opinion of the expert might be influenced by the working setting, but not by the experience in NMD (as measured in years).
Short-term outcome prediction for myasthenia gravis: an explainable machine learning model - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36860354/
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Conclusions: The explainable, ML-based predictive model can aid in forecasting the short-term outcome for MG with good accuracy in clinical practice.
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