Conclusions/Relevance: While the landscape for treatment of generalized MG has expanded over recent years, there is still an unmet need for patients for whom multiple lines of treatment have failed. The introduction of neonatal Fc receptor antagonists such as efgartigimod alfa may have an immediate impact in patients for whom standard-of-care...
The determinants of expert opinion in the development of care pathways: insights from an exploratory cluster analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36869326/
These findings might indicate a poor ability of the expert to discriminate what is not appropriate from what is not complete. Also, the opinion of the expert might be influenced...
Conclusions: These findings might indicate a poor ability of the expert to discriminate what is not appropriate from what is not complete. Also, the opinion of the expert might be influenced by the working setting, but not by the experience in NMD (as measured in years).
Short-term outcome prediction for myasthenia gravis: an explainable machine learning model - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36860354/
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Conclusions: The explainable, ML-based predictive model can aid in forecasting the short-term outcome for MG with good accuracy in clinical practice.
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Landscape analysis of m6A modification regulators related biological functions and immune characteristics in myasthenia gravis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36864526/
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Conclusions: Our findings suggested that m6A RNA modification had an important effect on immunity molecular mechanism of MG and provided a new perspective into understanding the pathogenesis of MG.
Association Between Myasthenia Gravis-Activities of Daily Living (MG-ADL) and EQ-5D-5L Utility Values: The Additional Effect of Efgartigimod on Utilities - Advances in Therapy
Source : https://link.springer.com/article/10.1007/s12325-023-02437-w
Introduction For patients with generalized myasthenia gravis (gMG), the association between symptom severity, often measured with the Myasthenia Gravis Activities of Daily Living (MG-ADL) instrument, and utility values is unknown....
Conclusions: Among patients with gMG, improvements in MG-ADL were significantly associated with higher utility values. MG-ADL scores alone were not sufficient to capture the utility gained from efgartigimod therapy.