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Post-Conference Summary of the American Academy of Neurology: AAN 2023 Annual Meeting

The 75th American Academy of Neurology (AAN) Annual Meeting took Boston by storm.

The six-day meeting, which was held at the Boston Convention and Exhibition Center from April 22 to 27, 2023, featured presentations, keynote lectures, abstracts, and posters on the latest advances in the diagnosis and treatment of a full spectrum of neurologic conditions, from epilepsy and stroke to migraine and movement disorders.

Click above for our post-conference wrap-up report.

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Outcomes of COVID-19 Infection and Vaccination Among Individuals With Myasthenia Gravis - PubMed

Outcomes of COVID-19 Infection and Vaccination Among Individuals With Myasthenia Gravis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37097637/

This study suggests that adults with MG who contracted COVID-19 had a higher risk of hospitalization and death compared with matched controls. Vaccine uptake was high, with negligible risk of...

Meaning: This population-based study suggests that patients with myasthenia gravis had a high risk of serious COVID-19 infection and worse outcomes compared with the general population, supporting the prioritization of this population for vaccination and early therapeutics for COVID-19.

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Efgartigimod Alfa

Efgartigimod Alfa

Source : https://www.ncbi.nlm.nih.gov/books/NBK588128/

No information is available on the clinical use of efgartigimod alfa during breastfeeding. Because efgartigimod alfa is a large protein molecule with a molecular weight of 54,000 Da, the amount...

Summary of Use During Lactation: No information is available on the clinical use of efgartigimod alfa during breastfeeding. Because efgartigimod alfa is a large protein molecule with a molecular weight of 54,000 Da, the amount in milk is likely to be very low. It is also likely to be partially destroyed in the infant's gastrointestinal tract...

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Preoperative respiratory muscle training combined with aerobic exercise improves respiratory vital capacity and daily life activity following surgical treatment for myasthenia gravis - Journal of Cardiothoracic Surgery

Preoperative respiratory muscle training combined with aerobic exercise improves respiratory vital capacity and daily life activity following surgical treatment for myasthenia gravis - Journal of Cardiothoracic Surgery

Source : https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-023-02283-5

Objective The effects of preoperative respiratory muscle training (RMT) on postoperative complications in patients surgically treated for myasthenia gravis (MG) remain unclear. The present study therefore evaluated the effects of...

Conclusion: RMT and aerobic exercise can have positive effects on postoperative respiratory vital capacity and daily life activity, and would enhance recovery after surgery in MG patients.

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2yr
Efgartigimod Alfa in Generalised Myasthenia Gravis: A Profile of Its Use - CNS Drugs

Efgartigimod Alfa in Generalised Myasthenia Gravis: A Profile of Its Use - CNS Drugs

Source : https://link.springer.com/article/10.1007/s40263-023-01000-z

Intravenous efgartigimod alfa (also known as efgartigimod alfa-fcab in the USA; Vyvgart®) is the first neonatal Fc receptor antagonist approved in several countries worldwide, including the USA and EU for...

Conclusions/Relevance: The clinical benefits of efgartigimod alfa were durable and reproducible. Furthermore, in an interim analysis of the ongoing open-label phase 3 ADAPT+ extension trial, efgartigimod alfa provided consistent clinically meaningful improvements in patients with gMG. Efgartigimod alfa was generally well tolerated, with most...