Causal effect of vitamin D on myasthenia gravis: a two-sample Mendelian randomization study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37538922/
This study provides the causal relationship between genetically predicted circulating vitamin D levels and MG and provides new insights into the genetics of MG.
Conclusion: This study provides the causal relationship between genetically predicted circulating vitamin D levels and MG and provides new insights into the genetics of MG.
Dexamethasone improves thymoma-associated myasthenia gravis via the AKT-mTOR pathway - Naunyn-Schmiedeberg's Archives of Pharmacology
Source : https://link.springer.com/article/10.1007/s00210-023-02641-z
Clinically, thymoma patients are often complicated with myasthenia gravis (MG). Dexamethasone, a glucocorticoid with anti-inflammatory effects, could be used as an immunosuppressant for thymoma-associated MG, but the mechanism of action...
Conclusions/Relevance: This study demonstrates that dexamethasone can promote apoptosis through the AKT-mTOR pathway for the treatment of thymoma-associated MG, as validated by network pharmacology predictions and clinical specimen experiments, and can be verified by large-scale clinical trials in the future. This study also provides...
Detection of Antibodies against the Acetylcholine Receptor in Patients with Myasthenia Gravis: A Comparison of Two Enzyme Immunoassays and a Fixed Cell-Based Assay - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37510896/
The detection of serum anti-acetylcholine receptor (AChR) antibodies is currently an important tool for diagnosing myasthenia gravis (MG) since they are present in about 85% of MG patients. Many serological...
Conclusions/Relevance: Overall, our findings show that the cELISA has better analytical performance than the iELISA and F-CBA. An ELISA has some advantages over CBAs, both live and fixed. First, a CBA undergoes subjective interpretation, which is related to the expertise of the reader and could undermine its reproducibility. Additionally, a...
Serum amino acid profiles in patients with myasthenia gravis - Amino Acids
Source : https://link.springer.com/article/10.1007/s00726-023-03303-3
Myasthenia gravis (MG) is an autoimmune disease characterized by weakness and rapid fatigue. Diagnostic methods used for myasthenia gravis are not conclusive and satisfactory, therefore it is necessary to develop...
Conclusions: This study showed that amino acids may be involved in mechanisms underlying myasthenia gravis pathogenesis and may also be considered as potential indicators of certain pathways altered in myasthenia. However, given the multifactorial, heterogeneous and complex nature of this disease, further work with a larger study group is...
Plasma Myokine Profiles in Patients With AChR- and MuSK-Ab-Positive Myasthenia Gravis
Source : https://thejcn.com/DOIx.php?id=10.3988/jcn.2022.0265
Seok JW, et al. J Clin Neurol. 2023 Jun;19:e44. https://doi.org/10.3988/jcn.2022.0265
Conclusions: The plasma myokine profile was significantly altered in patients with MG. FABP3 concentration may be useful in assessing disease severity and predicting the treatment response.