Safety of COVID-19 vaccine in patients with myasthenia gravis: a self-controlled case series study
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1141983/full
BackgroundThe safety of COVID-19 vaccines has been clarified in clinical trials; however, some immunocompromised patients, such as myasthenia gravis (MG) patients, are still hesitant to receive vaccines. Whether COVID-19 vaccination...
Conclusion: COVID-19 vaccination has no long-term impact on MG relapse.
Circulating CXCR5+ natural killer cells are expanded in patients with myasthenia gravis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37223338/
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Conclusion: These results reveal that CXCR5+ NK cells exhibit distinct phenotypes and functions compared with CXCR5− NK cells and might participate in the pathogenesis of MG.
Fungal Gut Microbiome in Myasthenia Gravis: A Sub-Analysis of the MYBIOM Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37233280/
An altered gut microbiota is a possible contributing pathogenic factor in myasthenia gravis (MG), an autoimmune neuromuscular disease. However, the significance of the fungal microbiome is an understudied and neglected...
Conclusions/Relevance: Besides one MG patient with abundant Ca. albicans, no prominent dysbiosis in the MG group of the mycobiome was found. Not all fungal sequences within all groups were successfully assigned, so further sub-analysis was withdrawn, limiting robust conclusions.
Evaluation of the quality of patient involvement in a patient-led analysis of the lived experience of a rare disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37231525/
In this patient-led analysis, patient council members, patient authors and non-patient authors had a positive experience of being involved in the project. We gained useful insights into elements that contributed...
Conclusion: In this patient-led analysis, patient council members, patient authors and non-patient authors had a positive experience of being involved in the project. We gained useful insights into elements that contributed to the project's success and ways to improve future patient-led projects on the lived experience.
Efficacy of Innovative Therapies in Myasthenia Gravis: Systematic Review, Meta-Analysis and Network Meta-Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37204031/
Anti-complement and FcRn treatments proved to be both effective in MG patients, whereas Rituximab did not show a significant benefit for patients. With the limitations of this meta-analysis, including efficacy...
Interpretation: Anti-complement and FcRn treatments proved to be both effective in MG patients, whereas Rituximab did not show a significant benefit for patients. With the limitations of this meta-analysis, including efficacy time-points, FcRn treatments showed a short-term higher effect on the QMG. Real-life studies with long-term...