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Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case-control study

Type 2 diabetes mellitus as a possible risk factor for myasthenia gravis: a case-control study

Source : https://www.frontiersin.org/articles/10.3389/fneur.2023.1125842/full

BackgroundA certain number of myasthenia gravis (MG) patients clinically had type 2 diabetes mellitus (T2DM) prior to MG onset, which suggests that the onset of MG may correlate with the...

Interpretation: This study demonstrates that T2DM is strongly associated with the subsequent risk of MG and varies significantly by sex and age. It reveals that diabetic MG may be a unique subtype that is different from the conventional MG subgroup classification. More clinical and immunological features of diabetic MG patients need to...

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Comparing the Impact of COVID-19 on Vaccinated and Unvaccinated Patients Affected by Myasthenia Gravis - PubMed

Comparing the Impact of COVID-19 on Vaccinated and Unvaccinated Patients Affected by Myasthenia Gravis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37109594/

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Conclusions: International and Italian guidelines have considered MG patients to be frail and prioritized their vaccination, as well as the vaccination of other patients affected by autoimmune diseases such as Multiple Sclerosis. Our data further support this view. The impact of SARS-CoV-2 infection was indeed considerably more negative in...

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Myasthenia gravis, respiratory function, and respiratory tract disease - PubMed

Myasthenia gravis, respiratory function, and respiratory tract disease - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37101094/

Myasthenia gravis (MG) is characterized by muscle weakness caused by autoantibodies that bind to the postsynaptic membrane at the neuromuscular junction and impair acetylcholine receptor function. Weakness of respiratory muscles...

Conclusions/Relevance: MG patients with respiratory muscle weakness need active immunosuppressive drug treatment long term, and they need regular specialist follow-up. Comorbidities affecting respiratory function need attention and optimal treatment. Respiratory tract infections can lead to MG exacerbations and precipitate an MG crisis....

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Post-Conference Summary of the American Academy of Neurology: AAN 2023 Annual Meeting

The 75th American Academy of Neurology (AAN) Annual Meeting took Boston by storm.

The six-day meeting, which was held at the Boston Convention and Exhibition Center from April 22 to 27, 2023, featured presentations, keynote lectures, abstracts, and posters on the latest advances in the diagnosis and treatment of a full spectrum of neurologic conditions, from epilepsy and stroke to migraine and movement disorders.

Click above for our post-conference wrap-up report.

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Outcomes of COVID-19 Infection and Vaccination Among Individuals With Myasthenia Gravis - PubMed

Outcomes of COVID-19 Infection and Vaccination Among Individuals With Myasthenia Gravis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37097637/

This study suggests that adults with MG who contracted COVID-19 had a higher risk of hospitalization and death compared with matched controls. Vaccine uptake was high, with negligible risk of...

Meaning: This population-based study suggests that patients with myasthenia gravis had a high risk of serious COVID-19 infection and worse outcomes compared with the general population, supporting the prioritization of this population for vaccination and early therapeutics for COVID-19.