Physician- and patient-reported perspectives on myasthenia gravis in Europe: a real-world survey - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37386469/
Our findings demonstrated the high burden of MG despite current treatment options for patients with MG.
Conclusions: Our findings demonstrated the high burden of MG despite current treatment options for patients with MG.
Summary of Research: Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis - Neurology and Therapy
Source : https://link.springer.com/article/10.1007/s40120-023-00514-4
This article provides a summary of a previously published paper: Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis. The paper reported the results of the CHAMPION-MG trial which investigated the...
Conclusions/Relevance: Ravulizumab improved symptoms and muscle strength compared with placebo in patients with gMG who had acetylcholine receptor antibodies, and its side effects were mild in most patients.
Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology - Acta Neuropathologica
Source : https://link.springer.com/article/10.1007/s00401-023-02603-y
Serum autoantibodies targeting the nicotinic acetylcholine receptor (AChR) in patients with autoimmune myasthenia gravis (MG) can mediate pathology via three distinct molecular mechanisms: complement activation, receptor blockade, and antigenic modulation....
Conclusions/Relevance: These findings provide new insight into the immunopathology of MG, demonstrating that single autoreactive clones can efficiently mediate multiple modes of pathology. Current therapeutic approaches targeting only one autoantibody-mediated pathogenic mechanism may be evaded by autoantibodies with multifaceted capacity.
Myasthenia-like paraneoplastic syndrome with multiple... : Medicine
ation with primary lung cancer remains unknown. Patient concerns: A 55-year-old female presented with slurred speech, weakness in chewing, sporadic difficulty in swallowing, and weakness in both lower limbs for...
Lessons: Although it is unclear why MG coexists with lung cancer, it is probable that MG is a paraneoplastic condition. Cerebrospinal fluid testing should be carried out along with electrophysiological, serological, and pharmacological procedures pertinent to the diagnosis of MG to thoroughly examine if people simultaneously experience...
Myasthenic crisis as an initial presentation of myasthenia gravis in an 81-year-old following endoscopic myotomy for Zenker's diverticulum
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269386/
In this article, we present the case of a patient with previously undiagnosed myasthenia gravis who underwent an endoscopic procedure for Zenker's diverticulum. The patient was readmitted due to ongoing...
Conclusions/Relevance: This case demonstrates that myasthenia gravis, although rare, can occur in elderly patients and present with other sequelae that may mask the underlying diagnosis.