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Did you know? In generalized myasthenia gravis, peripheral inflammatory markers such as NLR, PLR, SII, and SIRI are significantly elevated and correlate with disease severity. Elevated NLR and thymoma were independently associated with myasthenic crisis, while PLR was linked to MG onset—supporting their role in risk stratification.

Could routine monitoring of NLR and PLR enhance early identification of high-risk gMG patients?

NCCN Guidelines

Could routine monitoring of NLR and PLR enhance early identification of high-risk gMG patients?

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Triple M syndrome (myasthenia gravis, myocarditis and myositis) following atezolizumab in small cell lung carcinoma - PubMed

Triple M syndrome (myasthenia gravis, myocarditis and myositis) following atezolizumab in small cell lung carcinoma - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41763674/

An older adult in his early 80s with locally advanced small cell lung carcinoma was treated with carboplatin, etoposide and atezolizumab. After two well-tolerated cycles, he developed acute ocular and...

Case report describing immune checkpoint inhibitor-associated myasthenia gravis, myocarditis, and myositis following atezolizumab for small cell lung carcinoma, underscoring immune-related toxicity recognition, multidisciplinary management, and oncologic treatment trade-offs.

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Outcomes following single-level lumbar fusion in patients with myasthenia gravis - PubMed

Outcomes following single-level lumbar fusion in patients with myasthenia gravis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41717074/

Patients with MG experienced more postoperative complications and higher healthcare utilization after single-level lumbar fusion. These findings highlight the importance of individualized perioperative planning to mitigate risks and inform surgeon...

Database study found myasthenia gravis patients undergoing lumbar fusion had higher postoperative cardiopulmonary complications, pseudoarthrosis, revision surgery, readmissions, and emergency visits compared with matched controls.

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Genetic insights into biological aging and myasthenia gravis: a Mendelian randomization study of telomere length, epigenetic clocks, and mitochondrial DNA copy number - PubMed

Genetic insights into biological aging and myasthenia gravis: a Mendelian randomization study of telomere length, epigenetic clocks, and mitochondrial DNA copy number - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41691323/

Our findings demonstrate a bidirectional causality between EOMG and epigenetic aging clocks, which indicates that there is a self-reinforcing pathophysiological cycle. The epigenetic age acceleration is both a driver and...

Prospective study of 20 PAP-intolerant OSA patients found single-stage multilevel surgery significantly reduced AHI and Epworth scores, improved oxygenation, and achieved 65% surgical success without major complications.

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Myasthenia gravis following the initiation of statin therapy: A multinational self-controlled case series study - PubMed

Myasthenia gravis following the initiation of statin therapy: A multinational self-controlled case series study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41645666/

In this multinational SCCS study, statin initiation may be associated with increased risk of new-onset MG during the first 6-12 months, with greater magnitude of risk elevation for higher intensity...

Multinational self-controlled case series shows increased risk of new-onset myasthenia gravis within 6–12 months of statin initiation, particularly early and with higher-intensity statin therapy, using real-world population data.