Antibodies to neurofilament light as potential biomarkers in multiple sclerosis
Source : https://neurologyopen.bmj.com/content/3/2/e000192
Background and objective The concentration of neurofilament light (NfL) protein in cerebrospinal fluid (CSF) and blood is widely considered as a quantitative measure of neuro-axonal injury. Immune reactivity to NfL...
Conclusions:These results support the potential usefulness of quantifying antibody response to NfL as potential markers of progression and treatment response in MS and need to be considered when interpreting peripheral blood NfL levels.
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MS Connect4yrKey Points • Source: BMJ Neurology Open • Conclusion/Relevance: “These results support the potential usefulness of quantifying antibody response to NfL [neurofilament light] as potential markers of progression and treatment response in MS and Show More
Cognitive function and oral health in relapsing-remitting multiple sclerosis - Clinical Oral Investigations
Source : https://link.springer.com/article/10.1007/s00784-021-04272-1
Objectives Multiple sclerosis (MS) is often associated with reduced cognitive function, and there is also emerging evidence of a heightened vulnerability to oral health problems. However, although links between cognitive...
These data cross-validate previous research which shows people with RRMS are more likely to present with both reduced cognitive function and poorer oral health, but also extends this literature in a meaningful way by additionally showing for the first time that these clinical features are unrelated in RRMS.
T1/T2 ratio: A quantitative sensitive marker of brain tissue integrity in multiple sclerosis
Source : https://doi.org/10.1111/jon.12943
Background and Purpose The aim of this study is to determine whether cerebral white matter (WM) microstructural damage, defined by decreased fractional anisotropy (FA) and increased axial (AD) and r...
Conclusions:Results showed significant differences between RRMS and HC in both DTI and T1/T2 ratio measurements. T1/T2 ratio even demonstrated extensive WM abnormalities when compared to DTI, thereby highlighting the ratio's sensitivity to subtle differences in cerebral WM structural integrity using only conventional MRI sequences.
Highlights:
•In CLARIFY-MS, we are investigating the effect of cladribine tablets 3.5 mg/kg on health-related quality of life of patients with highly active relapsing multiple sclerosis.
•Here, we report on the design of CLARIFY-MS and results of an interim analysis of treatment satisfaction, safety, and tolerability at 6...
Effects of Vibration Training on Cognition and Quality of Life in People with Multiple Sclerosis
Background: Multiple sclerosis (MS) detrimentally affects cognition and quality of life (QOL). Interventions that can improve cognitive deficit and QOL in people with MS are desired. This pilot study investigated...
Conclusions: These results suggest that vibration training could be an effective alternative training paradigm to enhance cognition and QOL in people with MS, and they provide an encouraging base to conduct a large-scale clinical trial.