Hypogonadism in men with multiple sclerosis: Prevalence and clinical associations - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35123293/
It has been hypothesized that multiple sclerosis (MS) has hormonal influences, and testosterone may have anti-inflammatory functions in this context. Given prior reports of lower testosterone levels in men with...
Relevance: Given prior reports of lower testosterone levels in men with MS in archival serum samples, we evaluated the prevalence of hypogonadism in the clinical setting and its association with disability in men with MS.
Highlights:
•No difference between multiple sclerosis patients without treatment and healthy people in terms of COVID-19 vaccine response.
•Multiple sclerosis patients on disease-modifying treatment have lower antibody responses than those without treatment.
•mRNA vaccine resulted in a more significant antibody response than an inactivated...
Single-nucleus RNA-seq of normal-appearing brain regions in relapsing-remitting vs. secondary progressive multiple sclerosis
Source : https://www.biorxiv.org/content/10.1101/2022.01.10.475705v1
Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form, which can transform into secondary-progressive MS (SPMS)...
Notably, SPMS brains downregulated astrocytic sphingosine kinases (SPHK1/2) – the enzymes required to phosphorylate and activate the MS drug, fingolimod. This reduction was modeled with astrocyte-specific Sphk1/2 null mice in which fingolimod lost activity, supporting functionality of observed transcriptomic changes. These data provide an...
High or increasing serum NfL is predictive of impending multiple sclerosis relapses
Source : https://www.msard-journal.com/article/S2211-0348(22)00050-5/fulltext
With an expanding spectrum of disease-modifying treatments (DMTs) for patients with MS, the need for biomarkers that can identify patients at risk of impending disease activity who might benefit from...
Conclusion: We enumerate the risk of relapse associated with dynamic changes in sNfL. Both baseline and longitudinal change in sNfL may help identify patients who would benefit from early treatment optimisation.
Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35018577/
Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system (CNS) caused by CNS infiltration of peripheral immune cells, immune-mediated attack of the myelin sheath, neuroinflammation,...
PIGA1138-treatment, which increased neurosteroid allopregnanolone production, ameliorated all pathological biomarkers, while PIGA839, unable to activate neurosteroidogenesis in vivo, exerted only moderate/partial effects in MOG-EAE mice. Altogether, our results suggest that PIGA1138-based treatment may represent an interesting possibility to be...