Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis
Source : https://n.neurology.org/content/early/2022/03/11/WNL.0000000000200144
Objectives: To explore the relationship between slowly expanding lesions (SELs) on MRI and disability in secondary progressive multiple sclerosis (SPMS). Methods: We retrospectively studied 345 patients with SPMS enrolled in...
Conclusions: Definite SELs represent almost one third of T2 lesions in SPMS. They are associated with neurodegenerative MRI markers and related to clinical worsening, suggesting that they may contribute to disease progression and be a new target for therapeutic interventions.
High prevalence of intrathecal IgA synthesis in multiple sclerosis patients - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-08099-y
The detection of intrathecal IgA synthesis (IAS) in multiple sclerosis (MS) could be underestimated. To assess it, we develop a highly sensitive assay based on isoelectric focusing (IEF). 151 MS...
Conclusion/Relevance: Using IEF, MS patients showed higher percentage of IAS-IEF (43.00%) than the control group (16.98) (p = 0.001). The incidence was especially higher in patients with clinically isolated syndrome (66.00%). The new IFE demonstrated a higher percentage of IAS in MS patients than assumed in the past. The presence of...
A point-of-care diagnostic test for aquaporin-4 antibody seropositive neuromyelitis optica - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35247751/
doi: 10.1016/j.msard.2022.103716. Online ahead of print. 1 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States of America. 2 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States...
Conclusion: This point-of-care AQP4-Ab testing method may become a pragmatic option to diagnose AQP4-Ab seropositive NMOSD in difficult-to-reach settings. This method should be confirmed with other testing parameters and field tested in new populations.
A one year follow of patients with multiple sclerosis during COVID-19 pandemic: A cross-sectional study in Qom province, Iran
Source : https://www.msard-journal.com/article/S2211-0348(22)00227-9/fulltext
In December 2019, a cluster of unexplained pneumonia in Wuhan, China, penetrated borders and became a global pandemic. The current pandemic and the numerous unexplained issues regarding the post-pandemic phase,...
Conclusion:The present study showed a significant lower incidence of COVID-19 infection in MS patients. Except for clinical relapse, other demographic and MS characteristics, and DMT type were not associated with COVID-19 infection. In addition, COVID-19 vaccination reduced the risk of COVID-19 development, and the prognosis was favorable in the...
Neurology's vital role in preventing unnecessary and potentially harmful pediatric studies
Source : https://www.tandfonline.com/doi/abs/10.1080/14737175.2022.2045953?journalCode=iern20
Abstract Regulatory authorities recognize two human populations: adults and children defined as <18 years. For drug approval, they demand separate studies. But humans mature slowly during puberty. The 18 th...
Expert opinion: Young patients with multiple sclerosis and other neurological diseases deserve studies with therapeutic intentions. “Pediatric” careers have emerged in academia, regulatory authorities, and pharmaceutical companies. Institutional Review Boards/ Ethics Committees should suspend questionable “pediatric” studies and reject...