Immunoadsorption and plasma exchange-Efficient treatment options for neurological autoimmune diseases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34904748/
In summary, both IA and TPE were effective and safe procedures for treating neurological autoimmune diseases. However, there was a trend towards longer therapy response in patients treated with IA...
Results: A total of 32 patients were analyzed. Among these, 19 patients were treated with TPE and 13 patients with IA. IA and TPE therapy showed a comparable significant treatment response. In patients with MS and NMOSD, mean EDSS before and after treatment showed a significant reduction after treatment with IA. We observed a significant...
Myelin Peptide-Mannan Conjugate Multiple Sclerosis Vaccines: Conjugation Efficacy and Stability of Vaccine Ingredient
Source : https://www.mdpi.com/2076-393X/9/12/1456
Myelin peptide-mannan conjugates have been shown to be potential vaccines in the immunotherapy of multiple sclerosis. The conjugates are comprised from the epitope peptide and the polysaccharide mannan which transfers...
This study describes novel methods for the quantification of the vaccine ingredient peptide within the conjugate, a prerequisite for approval of clinical trials in the pursuit of multiple sclerosis therapeutics. Myelin peptides, such as MOG35–55, MBP83–99, and PLP131–145 in linear or cyclic form, as altered peptide ligands or conjugated to...
Marker of intrathecal immune activation for the evaluation of the IFN-β efficacy in relapsing-remitting multiple sclerosis
Source : https://zenodo.org/record/5761176
Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by a violation of the integrity of the blood-brain barrier, an expansion of autoreactive lymphocyte clones specific...
The identification of biomarkers that can help in the early evaluation of the response to a patient's treatment is necessary primarily for the individualized treatment of multiple sclerosis. In particular, cell-specific biomarkers of intra-inflammatory inflammation, which correlate with clinical manifestations of multiple sclerosis, can serve...
Highlights:
•Evidence has demonstrated the vital role of miRNAs in CNS development as important regulators of gene expression in all the phases of neurogenesis.
•The importance of miRNAs in neurogenesis, glial cells, and biofluids in MS has been discussed with the aim of assessing their potential as biomarkers for diagnosis and describing...
Conclusion: This cohort suggests that progressive visual failure in early multiple sclerosis predominantly affects males and is a bilateral disease associated with primary progressive multiple sclerosis.