Case Report: Successful Reversal of Residual Block with Sugammadex in a Patient Not Known to Have Myasthenia Gravis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36229945/
BACKGROUND Incomplete recovery from residual neuromuscular block agent (NMBA) after anesthesia is a serious adverse event in the post-anesthesia care unit. Acetylcholinesterase neostigmine is usually used to reverse residual neuromuscular...
Conclusion/Relevance: When refractory and prolonged residual neuromuscular blockade presents after repeated doses of anticholinesterase, sugammadex should be considered as an effective reversal agent. Particularly in cases of myasthenia gravis, sugammadex is superior to neostigmine for reversing rocuronium-induced NMBA in patients undergoing...
Efgartigimod for generalized myasthenia gravis with or without anti-acetylcholine receptor antibodies: a worldwide and Japanese perspective - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36227228/
doi: 10.1080/1744666X.2022.2136167. Online ahead of print. 1 Department of Neurology, Keio University School of Medicine, Tokyo. 2 Department of Neurology, Graduate School of Medicine, Chiba University, Chiba. 3 Department of...
Expert Opinion: Efgartigimod is a promising biological drug for patients with moderate to severe generalized MG with or without anti-acetylcholine receptor antibodies in Japan.
Enrichment of serum IgG4 in MuSK myasthenia gravis patients
Source : https://www.jni-journal.com/article/S0165-5728(22)00173-4/fulltext
Muscle-specific kinase (MuSK) myasthenia gravis (MG) is a neuromuscular autoimmune disease belonging to a growing group of IgG4 autoimmune diseases (IgG4-AIDs), in which the majority of pathogenic autoantibodies are of...
Conclusion: Although serum IgG4 levels are slightly increased, the levels do not support ubiquitous IgG4 responses in MuSK MG patients as the underlying cause of dominant IgG4 MuSK antibodies.
A Case Report and 31-Case Study: Does Takotsubo Cardiomyopathy in Myasthenia Gravis Patients Have a High Mortality Rate?
Myasthenia gravis is an autoimmune disorder in which antibodies are formed against post-synaptic nicotinic acetylcholine receptors that lead to impeded muscle contraction and commonly affects the oculomotor muscles. Takotsubo cardiomyopathy...
Relevance: We present a 66-year-old Caucasian male with a history of ocular myasthenia gravis who presented in a myasthenic crisis that was later diagnosed to have features suggestive of takotsubo cardiomyopathy.
A review of surgical management of progressive myogenic ptosis
Source : https://www.tandfonline.com/doi/abs/10.1080/01676830.2022.2122514?journalCode=iorb20
ABSTRACT Surgical correction of myogenic ptosis is a sophisticated endeavor, as the disease is progressive and the post-operative course is prone to significant complications. We sought to review the literature...
Conclusion: Like surgical repair for other forms of ptosis, correction of progressive myogenic ptosis is guided by levator excursion. However, myogenic ptosis is especially challenging as it is characterized by worsening ptosis and the loss of protective corneal mechanisms. The goals of care with myogenic ptosis involves repairing ptosis just...