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3yr
Preview of the 2022 American Academy of Neurology Fall Conference

This year’s American Academy of Neurology (AAN) Fall Conference is being held at Caesars Palace in Las Vegas with a virtual programming option from Oct. 28 to 30, 2022. At the AAN Fall Conference, participants will receive updates on relevant neurologic topics, attend practice management and science sessions, and network with other like-minded professionals. Click above for a preview of the conference.

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3yr
Thomas Willis' legacy on the 400th anniversary of his birth

Thomas Willis' legacy on the 400th anniversary of his birth

Source : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0042-1755278

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2022; 80(07): 759-762DOI: 10.1055/s-0042-1755278 O legado de Thomas Willis no 400° aniversário de seu nascimento 1   Universidade Federal do Paraná, Hospital de Clínicas,...


Relevance: To celebrate the 400th anniversary of the birth of Thomas Willis, his main contributions to the development of neurosciences, in particular neurology, are presented. Willis coined the term neurology and contributed significantly to the field of neuroanatomy, with the description of the arterial circle—located at the base of the...

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3yr
Successful Management of Generalized Myasthenia Gravis Induced by Atezolizumab in a Patient With Extensive-Stage SCLC: A Case Report

Successful Management of Generalized Myasthenia Gravis Induced by Atezolizumab in a Patient With Extensive-Stage SCLC: A Case Report

Source : https://www.jtocrr.org/article/S2666-3643(22)00078-9/fulltext

Immune checkpoint inhibitors including atezolizumab and durvalumab have been approved as the first-line treatment in extensive-stage SCLC. However, immune checkpoint inhibitors can cause immune-related adverse events, which will lead to...


Conclusion/Relevance: Herein we present a patient who developed generalized MG after receiving three cycles of treatment with etoposide, carboplatin, and atezolizumab. Immune-related MG was identified, with pyridostigmine bromide, intravenous immunoglobulin, and glucocorticoids given in time. Fortunately, the patient’s MG was relieved, and...

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3yr
Knowledge mapping of targeted immunotherapy for myasthenia gravis from 1998 to 2022: A bibliometric analysis

Knowledge mapping of targeted immunotherapy for myasthenia gravis from 1998 to 2022: A bibliometric analysis

Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.998217/full

BackgroundThe treatment of myasthenia gravis (MG) has advanced from steroids and traditional immunosuppressants to targeted immunotherapy. Targeted immunotherapy has been successfully employed in clinical practice in recent years. This study...


Conclusion: The current study summarized the global research trends concerning targeted immunotherapy for MG. Research interests gradually advanced from basic research to clinical research. MG treatment has entered a personalized precision treatment phase. Further investigations into new target molecules and high-quality randomized controlled...

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3yr
Diagnosing myasthenia gravis using orthoptic measurements: assessing extraocular muscle fatiguability

Diagnosing myasthenia gravis using orthoptic measurements: assessing extraocular muscle fatiguability

Source : https://jnnp.bmj.com/content/early/2022/10/19/jnnp-2022-329859

Introduction Diagnosing ocular myasthenia gravis (MG) can be challenging because serum antibodies are often not detected. We aimed to explore whether determining extraocular muscle (EOM) weakness using orthoptic measures, including...


Discussion: Orthoptic measurements can be used to diagnose MG by quantifying EOM weakness and fatiguability. Drift during persistent gaze on a Hess chart is specific for MG and could be used for diagnostic purposes. The Hess chart examination is widely available, inexpensive and fast. Moreover, orthoptic measurements may be a clinically relevant...