Chronic mimics of myasthenia gravis: a retrospective case series - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36753801/
Myasthenia gravis often presents a diagnostic challenge and may be misdiagnosed, particularly in seronegative disease with active symptoms. We retrospectively evaluated 61 patients following the introduction of single fibre electromyography...
Conclusions: We found myasthenic mimics should be suspected in disease that is static and treatment refractory, and functional mimics in disease with frequent flares. Thorough neurophysiologic assessment is important, particularly when making a diagnosis of seronegative myasthenia gravis.
Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36754834/
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Conclusions: Our study suggests that AChR autoantibodies are produced by nonmalignant, polyclonal B cells The new anti-CD20 treatment obinutuzumab might be considered in effectively treating AChR MG.
Complement Activation Profiles in Anti-AChR Positive Myasthenia Gravis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36752022/
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Conclusions: Markers indicative of complement activation are prominently increased in patients with AChR-Ab MG despite standard immunosuppressive therapies. Complement inhibition proximal to C5 cleavage should be explored for its potential therapeutic benefits in AChR-Ab MG.
Myasthenia gravis: Frequently asked questions
Source : https://www.ccjm.org/content/90/2/103
Myasthenia gravis is a disorder of neuromuscular junction transmission, the result of antibodies against the post-synaptic aspect of the neuromuscular junction. Its clinical hallmark is fatigable weakness of skeletal muscles,...
Conclusions: This review uses a question-and-answer format to provide up-to-date, high-yield, clinically relevant information on myasthenia gravis.
Kearns-Sayre Syndrome Masquerading as Myasthenia Gravis : Retinal Cases and Brief Reports
sthenia gravis (MG). Methods: Case report. Results: A 15-year-old male with a presumed diagnosis of MG presented with blurry vision, ophthalmoplegia, and ptosis. He was found to have a mitochondrial...
Conclusions: We report a case of KSS found to have a novel large-scale mtDNA deletion. The presence of a mitochondrial pigmentary retinopathy found on dilated examination led to reconsideration of the previous diagnosis of MG and ultimately led to the correct diagnosis of KSS.