Muscle and Muscle-like Autoantigen Expression in Myasthenia Gravis Thymus: Possible Molecular Hint for Autosensitization - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36979710/
The thymus is widely recognized as an immunological niche where autoimmunity against the acetylcholine receptor (AChR) develops in myasthenia gravis (MG) patients, who mostly present thymic hyperplasia and thymoma. Thymoma-associated...
Conclusions/Relevance: Our findings support the idea that altered muscle autoantigen expression, related with hyperplastic and neoplastic changes, may favor autosensitization in the MG thymus, and that molecular mimicry involving tumor-related muscle-like proteins may be a mechanism that makes thymoma prone to developing MG.
Demyelinating polyneuropathy combined with brachial plexopathy after nivolumab therapy for hodgkin lymphoma: a case report - BMC Neurology
Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-023-03177-8
Background Nivolumab is an immune checkpoint inhibitor that targets the programmed cell death-1 protein and is effective in treating advanced cancer. However, it is also associated with various immune-related neurological...
Conclusion: Our study indicates the possibility of nivolumab-induced neuropathies in cases involving muscle weakness with sensory abnormalities of the upper extremity following nivolumab administration in patients with advanced cancer. Comprehensive electrodiagnostic studies and magnetic resonance imaging are helpful in the differential...
Thymectomy in thymomatous generalized myasthenia gravis: An analysis of the prognosis and risk factors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36997293/
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Conclusions: Male sex and disease duration <11.5 weeks were independent predictors of CSR in TGMG post-thymectomy. Onset age <52.8y and ocular and limb muscle weakness at onset was associated with a higher probability of achieving CSR than onset age >52.8 y and bulbar muscle weakness. Female sex was an independent predictor of MG...
Clinical spectrum of myasthenia gravis: An institute... : Journal of Family Medicine and Primary Care
nvolving all myasthenia patients presenting to neurology and cardio-thoracic department from the year 2013 to 2020. The clinical findings, Osserman grade of severity, antibodies profile, computed scanning thorax findings and...
Conclusion: MG is a treatable autoimmune disorder with a variety of clinical, radiological, and histopathological findings.
COVID-19-associated AMPA-R and CRMP-5 autoimmune encephalitis in a patient with thymoma and myasthenia gravis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36950670/
Thymomas are associated with autoimmune disease, most commonly myasthenia gravis, and rarely with autoimmune encephalitis. More recently, viral triggers including COVID-19 have also been implicated in autoimmunity. We present a...
Discussion: Here, we present a case of a patient with pre-existing thymoma and MG who developed AMPA-R/CRMP-5 receptor autoimmune encephalitis in the setting of SARS-CoV-2 infection ….