Evaluation of the quality of patient involvement in a patient-led analysis of the lived experience of a rare disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37231525/
In this patient-led analysis, patient council members, patient authors and non-patient authors had a positive experience of being involved in the project. We gained useful insights into elements that contributed...
Conclusion: In this patient-led analysis, patient council members, patient authors and non-patient authors had a positive experience of being involved in the project. We gained useful insights into elements that contributed to the project's success and ways to improve future patient-led projects on the lived experience.
Efficacy of Innovative Therapies in Myasthenia Gravis: Systematic Review, Meta-Analysis and Network Meta-Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37204031/
Anti-complement and FcRn treatments proved to be both effective in MG patients, whereas Rituximab did not show a significant benefit for patients. With the limitations of this meta-analysis, including efficacy...
Interpretation: Anti-complement and FcRn treatments proved to be both effective in MG patients, whereas Rituximab did not show a significant benefit for patients. With the limitations of this meta-analysis, including efficacy time-points, FcRn treatments showed a short-term higher effect on the QMG. Real-life studies with long-term...
Neonatal Fc receptor blockade as emerging therapy in diseases with plasma exchange indications - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37183667/
Neonatal Fc receptor (FcRn) blockade may represent a mechanism similar to plasma exchange (PLEX) in reducing immunoglobulin levels and thus have a broad implication for apheresis practitioners. Although only efgartigimod...
Conclusions/Relevance: We encourage apheresis practitioners to be familiar with this class of drugs in order to better understand how these two therapies can be used either standalone, or in combination with other therapies as both FcRn antagonism and PLEX improve clinical state by reducing IgG levels and pathogenic antibodies.
Effect of Thymectomy on Outcomes of Myasthenia Gravis Patients: A Case-Control Study at a Tertiary Care Hospital
Background and objective Myasthenia gravis (MG) is an acquired autoimmune disease mediated by antibodies affecting the neuro-muscular junction on the postsynaptic membrane, resulting in neuromuscular transmission obstruction and, consequently, muscle...
Conclusions: Our findings indicate that none of the analysed groups had significantly worse outcomes as a result of the current clinical practice of thymectomy patient selection.
Neurological Adverse Effects of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T-Cell Therapy | Khalid | World Journal of Oncology
Source : https://www.wjon.org/index.php/WJON/article/view/1575
Farhan Khalid , Rajshree Gupta, Rajvi Gor, Dairya Gor, Vinit Singh, Hussam Eltoukhy Abstract Immune checkpoint inhibitors (ICPIs) and chimeric antigen receptor (CAR) T-cell constitute recently approved novel therapies targeted...
Conclusions/Relevance: Neurological complications involve the peripheral and central nervous system, including polyneuropathy, myositis, myasthenia gravis, demyelinating polyradiculopathy, myelitis, and encephalitis. If early recognized, the neurological complications can be treated effectively with steroids to reduce the potential of...