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Serum amino acid profiles in patients with myasthenia gravis - Amino Acids

Serum amino acid profiles in patients with myasthenia gravis - Amino Acids

Source : https://link.springer.com/article/10.1007/s00726-023-03303-3

Myasthenia gravis (MG) is an autoimmune disease characterized by weakness and rapid fatigue. Diagnostic methods used for myasthenia gravis are not conclusive and satisfactory, therefore it is necessary to develop...

Conclusions: This study showed that amino acids may be involved in mechanisms underlying myasthenia gravis pathogenesis and may also be considered as potential indicators of certain pathways altered in myasthenia. However, given the multifactorial, heterogeneous and complex nature of this disease, further work with a larger study group is...

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Plasma Myokine Profiles in Patients With AChR- and MuSK-Ab-Positive Myasthenia Gravis

Plasma Myokine Profiles in Patients With AChR- and MuSK-Ab-Positive Myasthenia Gravis

Source : https://thejcn.com/DOIx.php?id=10.3988/jcn.2022.0265

Seok JW, et al. J Clin Neurol. 2023 Jun;19:e44. https://doi.org/10.3988/jcn.2022.0265

Conclusions: The plasma myokine profile was significantly altered in patients with MG. FABP3 concentration may be useful in assessing disease severity and predicting the treatment response.

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Transient Neonatal Myasthenia Gravis: A Case Report

Transient Neonatal Myasthenia Gravis: A Case Report

Source : https://sciendo.com/article/10.2478/prilozi-2023-0036

Abstract Transient neonatal myasthenia gravis (TNMG) is a neuromuscular disorder that occurs in infants born from mothers with myasthenia gravis (MG) due to transplacental transfer of antibodies against the acetylcholine...

Conclusions/Relevance: Adequate management of the newborn resulted in a positive outcome and evident withdrawal of the symptoms. Although TNMG is one of the rare neuromuscular disorders in newborns that can be treated, a multidisciplinary approach in the management of pregnant women with MG and newborns through timely diagnosis and early...

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Conclusions: The 10-year PRs of hereditary polyneuropathies, HD, MG, and inherited muscle diseases in young South Korean males have been reported. These data could be valuable to understanding each neuromuscular disease in the young male population of South Korea.

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Efgartigimod improved health-related quality of life in generalized myasthenia gravis: results from a randomized, double-blind, placebo-controlled, phase 3 study (ADAPT) - PubMed

Efgartigimod improved health-related quality of life in generalized myasthenia gravis: results from a randomized, double-blind, placebo-controlled, phase 3 study (ADAPT) - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36598575/

There are substantial disease and health-related quality-of-life (HRQoL) burdens for many patients with myasthenia gravis (MG), especially for those whose disease symptoms are not well controlled. HRQoL measures such as...

Conclusions/Relevance: The substantial and durable improvements in HRQoL end points in this study demonstrate the broader benefit of treatment with efgartigimod beyond relief of immediate signs and symptoms of gMG.