Efficacy of Innovative Therapies in Myasthenia Gravis: a Systematic Review, Meta-Analysis and Network Meta-Analysis
Source : https://pubmed.ncbi.nlm.nih.gov/37204031/
Anti-complement and FcRn treatments both proved to be effective in MG patients, whereas rituximab did not show a significant benefit for patients. Within the limitations of this meta-analysis, including efficacy...
Approximately 15% of patients with gMG could be defined as nonresponders to standard therapy, and they experienced a high burden of the disease.
Eliciting Exploratory Patient Preference Data: a Case Study in a Rare Disease
Source : https://link.springer.com/article/10.1007/s40290-023-00509-4
Qualitative and quantitative methods provide different and complementary insights into patients' preferences for treatment. Objective The aim of this study was to use a novel, mixed-methods approach employing qualitative and...
The aim of this study was to use a novel, mixed-methods approach employing qualitative and quantitative approaches to generate preliminary insights into patient preferences for the treatment of generalized myasthenia gravis.
Refocusing Generalized Myasthenia Gravis: Patient Burden, Disease Profiles, and the Role of Evolving Therapy
Source : https://pubmed.ncbi.nlm.nih.gov/38117543/
gMG has a physical, mental, and social impact, resulting in a considerable burden of disease and substantially decreased QoL, despite standard treatments. The availability of novel, targeted treatments that influence...
The availability of novel, targeted treatments that influence key pathologic mediators of gMG together with new biomarkers offers the potential to optimize care management and enable more patients to achieve minimal manifestation status.
Brain Abscesses Caused by Listeria Monocytogenes in a Patient With Myasthenia Gravis - Case Report and Systematic Review
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705864/
Listeriosis is a known cause of community acquired bacterial meningitis/meningoencephalitis. It occurs more frequently in neonates, older people and immunocompromised hosts.
This case and literature review highlight the importance of Listeria monocytogenes as a highly lethal foodborne etiologic agent of brain abscesses, meningoencephalitis, and disseminated disease in populations at risk.
Residual Serum Fibrinogen as a Universal Biomarker for All Serotypes of Myasthenia Gravis
Source : https://www.nature.com/articles/s41598-023-47559-x
Myasthenia Gravis (MG) is an autoimmune disease associated with severe neuromuscular weakness. Diagnostic confirmation of MG is typically delayed and secured in about 85% and 50% of patients with generalized...
Researchers found the presence of high serum fibrinogen levels to be highly sensitive to MG with specificities that appear to be potentially superior to current clinical testing methods. High residual serum fibrinogen was also detected in all serotypes as well in class I patients.