Myasthenia gravis: the future is here
Source : https://pubmed.ncbi.nlm.nih.gov/39105625/
Myasthenia gravis (MG) stands as a prototypical antibody-mediated autoimmune disease: it is dependent on T cells and characterized by the presence of autoantibodies targeting proteins located on the postsynaptic surface...
Advancements in understanding MG subgroups have led to targeted therapies, improving treatment precision and outcomes in this autoimmune neuromuscular disorder.
Refocusing generalized myasthenia gravis: Patient burden, disease profiles, and the role of evolving therapy
Source : https://pubmed.ncbi.nlm.nih.gov/38117543/
gMG has a physical, mental, and social impact, resulting in a considerable burden of disease and substantially decreased QoL, despite standard treatments. The availability of novel, targeted treatments that influence...
Novel targeted treatments and biomarkers offer the potential to optimize management of generalized myasthenia gravis, improving patient outcomes, and reducing disease burden and enhancing quality of life.
Improvement of fatigue in generalised myasthenia gravis with zilucoplan
Source : https://pubmed.ncbi.nlm.nih.gov/38400914/
Treatment with zilucoplan demonstrated statistical and clinically meaningful improvements in fatigue scores and severity versus placebo during RAISE, which were sustained to Week 60 in RAISE-XT.
In the Phase 3 RAISE study, zilucoplan significantly improved fatigue in MG patients, with sustained benefits through Week 60 in the RAISE-XT extension.
Recommendations for the management of myasthenia gravis in Belgium
Source : https://pubmed.ncbi.nlm.nih.gov/38649556/
International guidelines on the treatment of myasthenia gravis (MG) have been published but are not tailored to the Belgian situation. This publication presents recommendations from a group of Belgian MG...
Belgian MG experts present tailored recommendations for managing generalized and ocular myasthenia gravis, addressing treatment sequences, comorbidities, and future therapies. A guide for Belgian neurologists.
Effects of acupuncture treatment for myasthenia gravis: A systematic review and meta-analysis
Source : https://pubmed.ncbi.nlm.nih.gov/38165870/
This meta-analysis demonstrated that acupuncture as an auxiliary may play a positive role in treating MG. It can improve the effective rate of treatment, and reduce TCM relative clinical score,...
Acupuncture may improve treatment efficacy and reduce clinical scores in myasthenia gravis. However, due to low study quality, further high-quality RCTs are needed to confirm these findings.