The disease burden of migraine patients receiving prophylactic treatments in Korea: a population-based claims database analysis - BMC Health Services Research
Source : https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-022-08191-z
Background Despite guideline recommendations, the limited benefits and failure of prophylactic treatment in patients with migraine have been reported. This study aimed to estimate the incremental burden (i.e., healthcare resource...
Conclusions: Migraine patients who received ≥1 prophylactic treatment had a higher burden of disease than migraine patients who received no prophylaxis. This indicates that despite migraine prophylaxis, the migraine-related disease burden remains high, and more efficient migraine prophylaxis strategies are needed.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrInformation for different ethnicities is important!
Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35822594/
These results are consistent with reported clinical data. Selectively blocking the CGRP receptor may have a greater impact on gastrointestinal transit than attenuating the activity of the ligand CGRP. This...
Conclusions: These results are consistent with reported clinical data. Selectively blocking the CGRP receptor may have a greater impact on gastrointestinal transit than attenuating the activity of the ligand CGRP. This differential effect may be related to physiologically opposing mechanisms between the CGRP and AMY1 receptors, as the CGRP...
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrGreat preclinical study
Comparison study between erenumab, fremanezumab, and galcanezumab in the preventive treatment of high frequency episodic migraine and chronic migraine - Neurological Sciences
Source : https://link.springer.com/article/10.1007/s10072-022-06254-x
The treatment of migraine now includes the possibility of using the anti CGRP monoclonal antibodies erenumab, fremanezumab and galcanezumab. Registration studies and real life studies have shown excellent efficacy and...
Relevance: Little is known about the possible differences between the three treatments and this observational study was conducted with a view to comparing the efficacy, safety and impact that anti-CGRP monclonal antibodies have on additional parameters such as disability in social, family and work activities.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThis is great study since there are usually not head to head studies.
Effectiveness of anti-CGRP monoclonal antibodies on central symptoms of migraine - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35775208/
1 Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy. 2 Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy. 1 Section...
Conclusion: Anti-calcitonin gene-related peptide antibodies seems to significantly impact brain functions of migraineurs, preventing not only migraine headache but also its anticipatory and accompanying symptoms.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrThis helps to relay the pathophysiology behind migraine.
Long-Term Follow-Up Safety and Effectiveness of CT-Guided Radiofrequency Thermocoagulation of Sphenopalatine Ganglion in Refractory Headache Treatment - Pain and Therapy
Source : https://link.springer.com/article/10.1007/s40122-022-00401-0
Objective The purpose of this study was to evaluate the effectiveness and safety of computed tomography (CT)-guided radiofrequency thermocoagulation (RFTA) of the sphenopalatine ganglion (SPG) for patients with refractory headache.
Conclusion: CT-guided RFTA of the SPG significantly relieves headache symptoms in patients with refractory migraine and CH. It has the advantages of rapid onset, long duration, and a safe and reliable treatment process, making it worthy of clinical application.
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Huma Sheikh, CEO, NY Neurology Medicine, PC3yrImportant research!