The sense of stopping migraine prophylaxis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36792981/
Translational and basic studies are warranted to investigate the long-term effects of a preventive drug after its discontinuation, starting from what is known about the biology of migraine. In addition,...
Conclusions: Translational and basic studies are warranted to investigate the long-term effects of a preventive drug after its discontinuation, starting from what is known about the biology of migraine. In addition, observational studies and, eventually, clinical trials focusing on the effect of discontinuation of migraine prophylactic...
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Huma Sheikh, CEO, NY Neurology Medicine, PC2yrThis is an important point.
Sex Hormones and Calcitonin Gene-Related Peptide in Women With Migraine: A Cross-sectional, Matched Cohort Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36813730/
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Conclusions: Different sex hormone profiles may influence CGRP concentrations in people, with current or past capacity to menstruate, with migraine. Measurement of CGRP in tear fluid was feasible and warrants further investigation.
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Huma Sheikh, CEO, NY Neurology Medicine, PC2yrThis is a good article.
Fremanezumab for Migraine Prevention in Japanese Elderly Aged Over 70 Years Old
Background Elderly migraine is a public health problem with prolonged life expectancy, and effective prophylactic treatment is needed. There were no reports on fremanezumab for the elderly. We described the...
Conclusions: We described the six elderly migraine patients aged over 70 years old treated with fremanezumab. Two (33.3%) of the six patients experienced therapeutic effectiveness. This is the first report of fremanezumab for elderly migraine patients aged over 70 years old. Further evidence accumulation is needed about CGRP-mABs for the...
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Huma Sheikh, CEO, NY Neurology Medicine, PC2yrgreat review article
A study of differential microRNA expression profile in migraine: the microMIG exploratory study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36797674/
A 3-miRNA (miR-342-3p, miR-532-3p and miR-758-5p) novel signature has been found differentially expressed between controls and patients with migraine. Enrichment analysis showed that these pathways are closely associated with known...
Conclusions: A 3-miRNA (miR-342-3p, miR-532-3p and miR-758-5p) novel signature has been found differentially expressed between controls and patients with migraine. Enrichment analysis showed that these pathways are closely associated with known migraine pathophysiology, which could lead to the first reliable epigenetic biomarker set. Further...
CGRP, Migraine, and Brain MRI in CADASIL: A Pilot Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36729391/
Migraine may forestall microangiopathy in CADASIL, though possibly independent of severity as measured by MRD. Interictal serum CGRP did not differ in our cohort suggesting CGRP may not be vital...
Conclusions: Migraine may forestall microangiopathy in CADASIL, though possibly independent of severity as measured by MRD. Interictal serum CGRP did not differ in our cohort suggesting CGRP may not be vital to migraine pathophysiology in CADASIL. Larger studies are needed to account for age differences.
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Huma Sheikh, CEO, NY Neurology Medicine, PC2yrVery interesting.