The patent foramen ovale may alter migraine brain activity: A pilot study of electroencephalography spectrum and functional connectivity analysis
Source : https://www.frontiersin.org/articles/10.3389/fnmol.2023.1133303/full
BackgroundA link has been shown between patent foramen ovale (PFO) and migraine, particularly migraine with aura. However, it is unknown if PFO might cause migraine by altering cortical excitability and...
Conclusion: The outcomes of this investigation suggested that PFO may change the cortical excitability in the occipital lobe of both migraineurs with and without aura. Meanwhile, the beta band PSD on the occipital area during photic stimulation might be an objective measure of severity in migraineurs with PFO.
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Huma Sheikh, CEO, NY Neurology Medicine, PC2yrThis may be how it can contribute to migraine.
Sex differences in clinical characteristics of migraine and its burden: A population-based study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36905094/
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Conclusion: Females have more severe disease, resulting in a much higher migraine disease burden than indicated by prevalence alone.
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Huma Sheikh, CEO, NY Neurology Medicine, PC2yrInteresting study.
Serum alpha-CGRP levels are increased in COVID-19 patients with headache indicating an activation of the trigeminal system - BMC Neurology
Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-023-03156-z
Background Headache is among the most frequent symptoms of acute COVID-19 infection. Its mechanisms remain obscure, but due to its migraine-like characteristics, the activation of the trigeminal system could account...
Conclusion: CGRP levels are increased in COVID-19 patients experiencing headache in the acute phase of this disease, which could explain why headache frequently occurs in COVID-19 and strongly supports a role for trigeminal activation in the pathophysiology of headache in this viral infection.
Patient-reported experiences with migraine-related cognitive symptoms: Results of the MiCOAS qualitative study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36905166/
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Conclusions: This patient-level qualitative study suggests that cognitive symptoms are common for persons with migraine, particularly in the pre-headache and headache phases. These findings highlight the importance of assessing and ameliorating these cognitive problems.
The NMDA receptor antagonists memantine and ketamine as anti-migraine agents - Naunyn-Schmiedeberg's Archives of Pharmacology
Source : https://link.springer.com/article/10.1007/s00210-023-02444-2
Migraine is a debilitating disorder affecting females more frequently than males. There is some evidence that drugs targeting glutamate receptors: memantine and ketamine might be beneficial in the therapy of...
Conclusions: Particular attention should be paid to people who have a treatment-resistant form of migraine with aura or have exhausted existing treatment options. For them, the drugs under discussion could represent an interesting alternative in the future.