The psychological benefits of neuropsychological assessment feedback as a psycho-educational therapeutic intervention: A randomized-controlled trial with cross-over in multiple sclerosis
Source : https://www.tandfonline.com/doi/abs/10.1080/09602011.2022.2047734?journalCode=pnrh20
ABSTRACT Evidence supporting the direct therapeutic benefits of neuropsychological assessment (NPA) feedback relies mostly upon post-feedback consumer surveys. This randomized-controlled trial with cross-over investigated the benefits of NPA feedback in...
Conclusion: Despite lack of improvement in the RCT component at 1-week post-NPA feedback, the absence of deterioration at this time, in addition to significant improvements in perceived cognitive functioning, self-efficacy and mood at follow-up, together with high satisfaction ratings, all support NPA feedback as a safe psycho-educational intervention that is followed by improved psychological wellbeing over time.
Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35334278/
In this longitudinal cohort we found no significant increased humoral or cellular response with administration of a third SARS-CoV-2 mRNA vaccination. These findings suggest the need for clinical strategies to...
Conclusion: In this longitudinal cohort we found no significant increased humoral or cellular response with administration of a third SARS-CoV-2 mRNA vaccination. These findings suggest the need for clinical strategies to include allowance of B cell reconstitution before repeat vaccination and/or provision of pre-exposure prophylactic monoclonal antibodies.
Synthesis and biological evaluation of Artemisinin derivatives as potential MS agents
Source : https://www.sciencedirect.com/science/article/abs/pii/S0960894X22001585?via=ihub
In this paper, a series of artemisinin derivatives were synthesized and evaluated. Studies have shown that IFN-γ produced by Th1 CD4+ T cells and IL-17A secreted by Th17 CD4+ T...
Relevance: In this paper, a series of artemisinin derivatives were synthesized and evaluated. Studies have shown that IFN-γ produced by Th1 CD4 T cells and IL-17A secreted by Th17 CD4 T cells played critical roles in the treatment of multiple sclerosis. We used different concentrations of artemisinin derivatives to inhibit Th1 / Th17 differentiation in naive CD4 T cells and to characterize IFN-γ / IL-17A in in vitro experiments.
Evaluation of peripapillary and subfoveal choroidal vascularity index in patients with multiple sclerosis
Source : https://www.sciencedirect.com/science/article/abs/pii/S1572100022000990?via=ihub
Available online 16 March 2022, 102810 * Peripapillary and sub-foveal choroidal tissue can be visualized using spectral-domain optical coherence tomography (OCT) in the EDI (enhanced depth imaging) mode. * It...
Conclusion: PCVI and SFCVI scores were significantly lower in MS patients compared to healthy controls. PCVI scores of MS patients who had a history of ON were significantly lower than those of patients without a previous ON attack, as were SFCVI scores. We consider that evaluation of PCVI and SFCVI might be useful for monitoring ocular involvement in patients with MS.
Association of Slowly Expanding Lesions on MRI With Disability in People With Secondary Progressive Multiple Sclerosis
Source : https://n.neurology.org/content/early/2022/03/11/WNL.0000000000200144
Objectives: To explore the relationship between slowly expanding lesions (SELs) on MRI and disability in secondary progressive multiple sclerosis (SPMS). Methods: We retrospectively studied 345 patients with SPMS enrolled in...
Conclusions: Definite SELs represent almost one third of T2 lesions in SPMS. They are associated with neurodegenerative MRI markers and related to clinical worsening, suggesting that they may contribute to disease progression and be a new target for therapeutic interventions.
High prevalence of intrathecal IgA synthesis in multiple sclerosis patients - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-08099-y
The detection of intrathecal IgA synthesis (IAS) in multiple sclerosis (MS) could be underestimated. To assess it, we develop a highly sensitive assay based on isoelectric focusing (IEF). 151 MS...
Conclusion/Relevance: Using IEF, MS patients showed higher percentage of IAS-IEF (43.00%) than the control group (16.98) (p = 0.001). The incidence was especially higher in patients with clinically isolated syndrome (66.00%). The new IFE demonstrated a higher percentage of IAS in MS patients than assumed in the past. The presence of IAS-IEF in MS is higher than in other neurological diseases.