Towards new perspectives: A scoping review and meta-synthesis to redefine brain health for multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38226556/
Brain health should be considered a primary target for optimal disease and lifestyle management across the MS disease course. A working definition reflecting a shift from a medical lens towards...
A scoping review on brain health in multiple sclerosis identified 70 evidence sources, highlighting definitions, outcome measures (mainly MRI), and lifestyle factors like physical activity, smoking avoidance, and diet.
MS care: integrating advanced therapies and holistic management - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38351950/
Lifestyle and environmental factors are key determinants in disease causality and progression in neurological conditions, including multiple sclerosis (MS). Lack of exercise, poor diet, tobacco smoking, excessive alcohol intake, social...
Lifestyle and environmental factors impact multiple sclerosis progression. Adopting brain-healthy, metabolically-healthy habits, alongside disease-modifying therapies, and emphasizing self-management with a multidisciplinary approach, can improve outcomes in MS patients.
Impact of Lifestyle Interventions on Multiple Sclerosis: Focus on Adipose Tissue - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39339700/
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by demyelination in the central nervous system (CNS), affecting individuals globally. The pathological mechanisms underlying MS remain unclear, but current evidence...
This review explores the role of adipose tissue, adipokines, and lifestyle factors like physical activity and nutrition in modulating inflammation and immune responses, aiming to improve multiple sclerosis management and quality of life.
Cognitive-motor dual-task training improves dynamic stability during straight and curved gait in patients with multiple sclerosis: a randomized controlled trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37997324/
Cognitive-motor DT implemented into the neurorehabilitation conventional program could be a useful strategy for gait and balance rehabilitation.
This study demonstrates that cognitive-motor dual-task training (DT) improves dynamic gait quality, stability, symmetry, and smoothness in people with multiple sclerosis (PwMS), supporting its effectiveness in neurorehabilitation.
Bioavailability as Proof to Authorize the Clinical Testing of Neurodegenerative Drugs-Protocols and Advice for the FDA to Meet the ALS Act Vision - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39337696/
Although decades of intensive drug discovery efforts to treat neurodegenerative disorders (NDs) have failed, around half a million patients in more than 2000 studies continue being tested, costing over USD...
The study suggests that the FDA should focus on improving drug bioavailability across the blood-brain barrier for neurodegenerative diseases, requiring proof of brain entry for IND approval and reconsidering biomarker reliance.