Effects of Vibration Training on Cognition and Quality of Life in People with Multiple Sclerosis
Background: Multiple sclerosis (MS) detrimentally affects cognition and quality of life (QOL). Interventions that can improve cognitive deficit and QOL in people with MS are desired. This pilot study investigated...
Conclusions: These results suggest that vibration training could be an effective alternative training paradigm to enhance cognition and QOL in people with MS, and they provide an encouraging base to conduct a large-scale clinical trial.
Case Report: Recurrent Severe Uveitis Secondary to Primary Progressive Multiple Sclerosis Responsive to Ocrelizumab
Source : https://doi.org/10.1080/09273948.2021.1980809
ABSTRACT Purpose: To report a case of severe, recurrent bilateral panuveitis secondary to primary progressive multiple sclerosis responsive to ocrelizumab infusions. Observation: We describe the clinical progression of a 40...
Conclusion: Six-monthly 600mg ocrelizumab infusions may be effective as a steroid sparing option for patients with severe, recurrent bilateral panuveitis secondary to primary progressive multiple sclerosis.
Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis - Nature Reviews Neurology
Source : https://www.nature.com/articles/s41582-021-00581-x
Despite substantial progress in the development of disease-modifying therapies for multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) remain limited. The authors present criteria for therapeutic success in...
Key points:
- Prominent pathological features of progressive multiple sclerosis (PMS) include global brain atrophy, slowly expanding lesions and a predominantly microglia/macrophage-mediated inflammatory response.
- Neurodegeneration in MS seems to be driven by a complex interplay between compartmentalized neuroinflammation, oxidative stress,...
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis
Source : https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.1c00926
Multiple Sclerosis is a chronic autoimmune neurodegenerative disorder of the central nervous system (CNS) that is characterized by inflammation, demyelination, and axonal injury leading to permeant disability. In the early...
Herein, we describe the discovery of BIIB091, a structurally distinct orthosteric ATP competitive, reversible inhibitor that binds the BTK protein in a DFG-in confirmation designed to sequester Tyr-551, an important phosphorylation site on BTK, into an inactive conformation with excellent affinity. Preclinical studies demonstrated BIB091 to be...
Patients experiences with multiple sclerosis disease-modifying therapies in daily life - a qualitative interview study - BMC Health Services Research
Source : https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-021-07012-z
Background Besides coping with a disease with many uncertainties, people with relapsing-remitting multiple sclerosis face complex decisions concerning disease-modifying therapies (DMTs). In an interview study, we aimed to assess patients'...
Conclusions: The study provides a rich and nuanced amount of patients’ experiences with DMTs. The findings demonstrate the importance for practitioners to look at current life circumstances of patients with multiple sclerosis when recommending a DMT and to promote and enable patients to make informed decisions.
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MS Connect4yrKey Points • Source: BMC Health Services Research • Conclusion/Relevance: “The study provides a rich and nuanced amount of patients’ experiences with DMTs. The findings demonstrate the importance for practitioners to look Show More