Fluid biomarkers in multiple sclerosis: Indicators of disease activity, progression, and treatment response - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42143974/
Multiple sclerosis (MS) is a chronic immune-mediated CNS disorder marked by inflammation, demyelination, and neurodegeneration. Standard clinical evaluation, neurological exams, disability scoring, and MRI often miss subclinical activity and poorly...
Review highlights fluid biomarkers including NfL, GFAP, CHI3L1, and CXCL13 for monitoring multiple sclerosis activity, progression, neurodegeneration, and treatment response, supporting improved prognostication and personalized therapeutic decision-making.
The influence of adolescent diet on the occurrence of late-onset multiple sclerosis: a population-based case-control study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42070054/
This research highlights the advantageous impact of dairy products, seafood, nuts, fruits, and vegetables in lowering the LOMS odds. Hence, advocating for nutrition role in development of LOMS could represent...
Higher adolescent intake of dairy, seafood, nuts, fruits, and vegetables was associated with reduced odds of late-onset multiple sclerosis, suggesting diet may play a preventive role in susceptible individuals.
Development of The Cognitive Estimation Test (BiTAHT) in healthy population and evaluation of reliability in individuals with multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42108237/
BiTAHT may be used to assess cognitive estimation abilities in Turkish adults and support future research on cultural validity. Although differences were observed between healthy controls and pwMS, these should...
Validation study developed the BiTAHT cognitive estimation test and demonstrated differences between healthy controls and multiple sclerosis patients, supporting culturally adapted neuropsychological assessment of executive and cognitive estimation abilities.
C3 and C5 Complement Cascade Activation in Brain Injury and Disease: Molecular Mechanisms, Pathological Roles, and Therapeutic Implications - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/42025804/
The complement system represents a crucial component of innate immunity with increasingly recognized roles in central nervous system pathology and homeostasis. Complement components C3 and C5 serve as central molecular...
Review highlights complement C3/C5 activation in multiple sclerosis, driving neuroinflammation, synaptic dysfunction, and neuronal injury, while presenting dual neuroprotective roles and emerging therapeutic and biomarker opportunities.
Multiple sclerosis: molecular pathogenesis and therapeutic intervention - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41034190/
Multiple sclerosis is a chronic immune-mediated disorder of the central nervous system characterized by demyelination, axonal loss, and neuroinflammation, culminating in progressive neurological disability. Despite significant advances in understanding its...
Multiple sclerosis is an immune-mediated CNS disorder causing demyelination and neurodegeneration. Advances in antigen-specific immunotherapy aim to restore immune tolerance, offering targeted treatment strategies beyond conventional immunosuppression.