Predicting upper limb disability progression in primary progressive multiple sclerosis using machine learning and statistical methods
Source : https://ieeexplore.ieee.org/abstract/document/9669665
Multiple sclerosis (MS) is a heterogeneous immune-mediated disorder of the central nervous system, and primary progressive MS (PPMS) is characterized by insidious injury independent of clinical relapses from disease onset....
To our knowledge, this is the first study to systematically evaluate ML models and statistical methods for predicting progression in PPMS using a well-characterized clinical trial cohort.
Pregnancy‐induced brain MRI changes in women with multiple sclerosis
Source : https://onlinelibrary.wiley.com/doi/10.1111/ene.15245
Corresponding Author Tomas Uher Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic Corresponding Author: Tomas...
Conclusions: The postpartum period was associated with an increase in T2 lesion volume and accelerated brain volume loss in a considerable proportion of women. This should be considered in treatment decision-making and designing clinical trials.
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Source : https://www.science.org/doi/10.1126/science.abj8222
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Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.
Hydroxychloroquine for Primary Progressive Multiple Sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34590328/
1 Department of Clinical Neurosciences, University of Calgary, Calgary, Canada. 2 Department of Community Health Sciences, University of Calgary, Calgary, Canada. 3 Department of Neurology and Neurosurgery, McGill University, Montreal,...
Interpretation: HCQ treatment was associated with reduced disability worsening in people with PPMS. HCQ is a promising treatment candidate in PPMS and should be investigated further in randomized controlled clinical trials.
Epilepsy as a predictor of disease progression in multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34595974/
1 Department of Neurology, University Medicine Greifswald, Ferdinand-Sauerbruchstraße, 17475 Greifswald, Germany. 2 Department of Neurology, University Medicine Greifswald, Greifswald, Germany. 3 German MS Register by the German MS Society, MS...
Conclusion: This work highlights the association of epilepsy on disability progression in MS, and the need for additional data to further clarify the underlying mechanisms.