Understanding multiple sclerosis as a disease spectrum: above and below the clinical threshold
Source : https://pubmed.ncbi.nlm.nih.gov/38535979/
Aligning on a consistently-applied mechanistic framework at distinct levels of explanation will enable greater precision across bench and clinical research, and inform discourse on drivers of disability progression and delivery...
Adopting a unified mechanistic framework for MS will enhance precision in research, prognostication, and treatment, bridging gaps between pathobiology and clinical outcomes.
Artificial Intelligence and Multiple Sclerosis
Source : https://pubmed.ncbi.nlm.nih.gov/38940994/
In this paper, we analyse the different advances in artificial intelligence (AI) approaches in multiple sclerosis (MS). AI applications in MS range across investigation of disease pathogenesis, diagnosis, treatment, and...
AI promises significant advancements in MS management, enhancing diagnosis, prognosis, and treatment personalization. Ensuring model interpretability and transparency will be crucial for clinical integration.
The use of modafinil for the treatment of fatigue in multiple sclerosis: A systematic review and meta-analysis of controlled clinical trials
Source : https://pubmed.ncbi.nlm.nih.gov/38988104/
The data indicates that modafinil confers a therapeutic benefit when treating fatigue in patients with MS and improves overall quality of life; however, there is a risk of precipitating adverse...
Modafinil reduces fatigue in MS patients and improves quality of life, but with increased risk of adverse events. More robust evidence is needed for clinical management.
Application of Theiler's murine encephalomyelitis virus in treatment of multiple sclerosis
Source : https://pubmed.ncbi.nlm.nih.gov/38989030/
Theiler's murine encephalomyelitis virus (TMEV) infected mice have been often used as an animal model for Multiple sclerosis (MS) due to their similar pathology in the central nervous system (CNS)....
The review summarizes drugs tested in the TMEV-induced MS model, aiming to guide treatments and offer theoretical insights for virus-induced multiple sclerosis.
Multiple sclerosis treatment review for primary care providers
Source : https://pubmed.ncbi.nlm.nih.gov/38915149/
The treatment landscape for multiple sclerosis has dramatically grown in terms of available options and complexity. The various mechanisms of action and safety profiles of these new treatments necessitate that...
The treatment landscape for multiple sclerosis has expanded with complex options, requiring primary care providers to stay updated on mechanisms, safety profiles, and practice guidelines for high-quality care.