Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Source : https://www.science.org/doi/10.1126/science.abj8222
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Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.
Hydroxychloroquine for Primary Progressive Multiple Sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34590328/
1 Department of Clinical Neurosciences, University of Calgary, Calgary, Canada. 2 Department of Community Health Sciences, University of Calgary, Calgary, Canada. 3 Department of Neurology and Neurosurgery, McGill University, Montreal,...
Interpretation: HCQ treatment was associated with reduced disability worsening in people with PPMS. HCQ is a promising treatment candidate in PPMS and should be investigated further in randomized controlled clinical trials.
Epilepsy as a predictor of disease progression in multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34595974/
1 Department of Neurology, University Medicine Greifswald, Ferdinand-Sauerbruchstraße, 17475 Greifswald, Germany. 2 Department of Neurology, University Medicine Greifswald, Greifswald, Germany. 3 German MS Register by the German MS Society, MS...
Conclusion: This work highlights the association of epilepsy on disability progression in MS, and the need for additional data to further clarify the underlying mechanisms.
Conclusion: The highest observed atherosclerosis risk factor among pwMS was smoking. Diabetes mellitus was the least reported risk factor in our population as a whole. Overall, and in participants with RRMS, dyslipidemia and hypertension were the second and third most commonly reported risk factors, however, hypertension exceeded dyslipidemia...
Although the exact causes of MS are not fully understood, genetic and environmental factors are thought to control MS onset and progression. In this article, we review the main immunological mechanisms involved in MS pathogenesis.