Early predictive risk factors for dimethyl fumarate-associated lymphopenia in patients with multiple sclerosis
Source : https://www.msard-journal.com/article/S2211-0348(22)00184-5/fulltext
Delayed-release dimethyl fumarate (DMF; Tecfidera, Biogen, Weston, MA) is an oral disease-modifying therapy (DMT) approved for the treatment of adult patients with relapsing multiple sclerosis (RMS) (Tecfidera, 2014). During the...
Conclusions: A pronounced reduction in ALCs early after initiation of DMF in MS patients is the best predictive risk factor for the subsequent development of significant lymphopenia.
Incidence, prevalence, and characteristics of heart failure among patients with multiple sclerosis: A systematic review and meta-analysis
Source : https://www.msard-journal.com/article/S2211-0348(22)00180-8/fulltext
Multiple sclerosis (MS) is the most common neurological autoimmune disease, whose symptoms often begin early in adulthood(Addy and Robin, 1981). It occurs due to progressive myelin degeneration within the central...
Conclusion: In conclusion, this study demonstrates that patients with MS are at an elevated risk of developing heart failure compared to the general population, which highlights the importance of regular and thorough checkups in PwMS in an effort to better detect any cardiovascular abnormality, dysfunction, or disease as soon as possible to...
Comorbidity in multiple sclerosis: Emphasis on patient-reported outcomes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35123292/
Comorbidity is a relevant issue in multiple sclerosis as half of people with MS report concomitant conditions. Hypertension, depression, and anxiety are especially prevalent in MS. In our study, comorbidity...
Conclusion: Comorbidity is a relevant issue in multiple sclerosis as half of people with MS report concomitant conditions. Hypertension, depression, and anxiety are especially prevalent in MS. In our study, comorbidity is associated with quality of life and fatigue, but not relapse rate. Depression and anxiety are independently associated with...
Hypogonadism in men with multiple sclerosis: Prevalence and clinical associations - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35123293/
It has been hypothesized that multiple sclerosis (MS) has hormonal influences, and testosterone may have anti-inflammatory functions in this context. Given prior reports of lower testosterone levels in men with...
Relevance: Given prior reports of lower testosterone levels in men with MS in archival serum samples, we evaluated the prevalence of hypogonadism in the clinical setting and its association with disability in men with MS.
Highlights:
•No difference between multiple sclerosis patients without treatment and healthy people in terms of COVID-19 vaccine response.
•Multiple sclerosis patients on disease-modifying treatment have lower antibody responses than those without treatment.
•mRNA vaccine resulted in a more significant antibody response than an inactivated...