Practical Recommendations from the Gulf Region on the Therapeutic Use of Cladribine Tablets for the Management of Relapsing Multiple Sclerosis: Impact of the Latest Real-World Evidence on Clinical Practice
Source : https://pubmed.ncbi.nlm.nih.gov/39097537/
Cladribine tablets (CladT), like alemtuzumab, acts as an immune reconstitution therapy. However, CladT is administered orally (alemtuzumab is given by infusion) and without the potential for serious side effects that...
Cladribine tablets offer effective, well-tolerated immune reconstitution therapy for MS, providing long-term freedom from disease activity, with potential benefits for DMT-naïve patients and early intervention strategies.
Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review
Source : https://pubmed.ncbi.nlm.nih.gov/39266777/
Multiple sclerosis (MS) is a demyelinating neurological disorder with a highly heterogeneous clinical presentation and course of progression. Disease-modifying therapies are the only available treatment, as there is no known...
MRI-based machine learning offers promising potential for predicting multiple sclerosis progression, highlighting the need for integrating imaging biomarkers with multimodal patient data to enhance personalized healthcare approaches.
Diversity and representation within the literature on sexual dysfunction in multiple sclerosis: A systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39032400/
Sex, gender identity, sexual orientation, and ethnicity are poorly reported in studies on SD in MS. These variables must be adequately evaluated to ensure research applies across diverse MS patient...
Sex, gender identity, sexual orientation, and ethnicity are inadequately reported in studies on sexual dysfunction in multiple sclerosis, hindering the applicability of findings across diverse patient populations.
Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38858520/
Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal damage. Early recognition and treatment are important for preventing...
Integrating oculomics with existing diagnostic methods offers a promising future for developing non-invasive, cost-effective tools for early detection and diagnosis of Multiple Sclerosis, enhancing patient outcomes.
The iron maiden: Oligodendroglial metabolic dysfunction in multiple sclerosis and mitochondrial signaling - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38950685/
Multiple sclerosis (MS) is an autoimmune disease, governed by oligodendrocyte (OL) dystrophy and central nervous system (CNS) demyelination manifesting variable neurological impairments. Mitochondrial mechanisms may drive myelin biogenesis maintaining the...
Thyroid hormone regulation is crucial for oligodendrocyte function and myelin biogenesis; dysregulation in multiple sclerosis leads to impaired lipid biosynthesis, mitochondrial dysfunction, and neurodegeneration, exacerbating disease progression.