A point-of-care diagnostic test for aquaporin-4 antibody seropositive neuromyelitis optica - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35247751/
doi: 10.1016/j.msard.2022.103716. Online ahead of print. 1 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States of America. 2 Department of Neurology, Massachusetts General Hospital, Boston, MA, United States...
Conclusion: This point-of-care AQP4-Ab testing method may become a pragmatic option to diagnose AQP4-Ab seropositive NMOSD in difficult-to-reach settings. This method should be confirmed with other testing parameters and field tested in new populations.
A one year follow of patients with multiple sclerosis during COVID-19 pandemic: A cross-sectional study in Qom province, Iran
Source : https://www.msard-journal.com/article/S2211-0348(22)00227-9/fulltext
In December 2019, a cluster of unexplained pneumonia in Wuhan, China, penetrated borders and became a global pandemic. The current pandemic and the numerous unexplained issues regarding the post-pandemic phase,...
Conclusion:The present study showed a significant lower incidence of COVID-19 infection in MS patients. Except for clinical relapse, other demographic and MS characteristics, and DMT type were not associated with COVID-19 infection. In addition, COVID-19 vaccination reduced the risk of COVID-19 development, and the prognosis was favorable in the...
Neurology's vital role in preventing unnecessary and potentially harmful pediatric studies
Source : https://www.tandfonline.com/doi/abs/10.1080/14737175.2022.2045953?journalCode=iern20
Abstract Regulatory authorities recognize two human populations: adults and children defined as <18 years. For drug approval, they demand separate studies. But humans mature slowly during puberty. The 18 th...
Expert opinion: Young patients with multiple sclerosis and other neurological diseases deserve studies with therapeutic intentions. “Pediatric” careers have emerged in academia, regulatory authorities, and pharmaceutical companies. Institutional Review Boards/ Ethics Committees should suspend questionable “pediatric” studies and reject...
Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis - Molecular Biology Reports
Source : https://link.springer.com/article/10.1007/s11033-022-07223-5
Multiple sclerosis (MS) is a chronic and complex neurodegenerative disease, distinguished by the presence of lesions in the central nervous system (CNS) due to exacerbated immunological responses that inflict oligodendrocytes...
Relevance: In this review, we focused on the exacerbated immune attack on nerve cells and the role of the cannabinoids and its interaction with the ECS in CNS during MS pathology.
Evolution of Anti-B Cell Therapeutics in Autoimmune Neurological Diseases - Neurotherapeutics
Source : https://link.springer.com/article/10.1007/s13311-022-01196-w
B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antigen-presenting cells facilitating antibody production but also as sensors, coordinators, and regulators...
Conclusion/Relevance: The paper summarizes basic aspects of B cell biology, discusses the roles of B cells in neurological autoimmunities, and highlights how the currently available or under development anti-B cell therapeutics exert their action in the wide spectrum and immunologically diverse neurological disorders. The efficacy of the various...