Therapeutic potential of IFIT2 in human diseases - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41046825/
The interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) is a crucial member of the interferon-stimulated gene (ISG) family, widely acknowledged for its antiviral activity. IFIT2 functions primarily through AU-rich RNA...
This review examines IFIT2’s roles in antiviral defense, cancer, autoimmunity, neurological disorders, and metabolic diseases, proposing its translational promise as a biomarker and therapeutic target in multiple pathologies including MS.
Determinants of clinical trial failure in multiple sclerosis: insights from ClinicalTrials.gov - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41001525/
One out of four MS clinical trials fails. Increasing the number of study sites and improving recruitment strategies could enhance their success rates.
Analysis of 282 MS clinical trials found 25% failed, mainly due to low recruitment, business decisions, and logistics. Trials with larger sites and safety endpoints showed higher success, emphasizing recruitment improvement.
Positive cerebrospinal fluid in the 2024 McDonald criteria for multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40967951/
The 2024 McDonald diagnostic criteria for Multiple Sclerosis (MS) introduce kappa free light chains (κ-FLC) detection in cerebrospinal fluid (CSF) which can be used interchangeably with oligoclonal IgG bands (OCB)...
The 2024 McDonald criteria integrate kappa free light chain detection in cerebrospinal fluid as an alternative to oligoclonal bands, enhancing diagnostic accuracy and offering prognostic insights for both pediatric and adult MS.
Association of Spinal Cord Radiomic Features and Disability in Multiple Sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40947502/
Radiomics identified pathological changes in pwMS in varying stages of the disease course that are undetectable by conventional spinal cord MRI. Radiomics may increase the yield of spinal cord MRI...
Radiomic analysis of spinal cord MRI in multiple sclerosis patients detected pathological changes undetectable by conventional imaging, distinguishing subgroups and correlating with disability more strongly than traditional measures, suggesting biomarker potential.
Target trial emulation to replicate randomised clinical trials using registry data in multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40908119/
The combined use of a TTE methodology and high-quality registry data is a valid tool to evaluate treatment effectiveness in MS.
This multicentre study used target trial emulation with French MS registry data to replicate eight RCTs of disease-modifying therapies, confirming validity of observational data for real-world treatment effectiveness evaluation.