New-Onset Multiple Sclerosis in Pregnancy: Diagnostic Approaches and Treatment Dilemmas - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39618752/
Multiple sclerosis (MS) is an autoimmune disease of the CNS affecting the brain, spinal cord, and optic nerves. Research consistently shows that relapse rates in MS decrease during pregnancy, particularly...
This case describes new-onset multiple sclerosis during pregnancy with rapid neurological decline, highlighting MRI and CSF findings crucial for diagnosis, therapeutic challenges, and the need for multidisciplinary management to balance maternal-fetal outcomes.
Comparative analysis of plasma proteolytic profiles in multiple sclerosis patients with and without a history of COVID-19 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41167049/
MS is associated with persistent quantitative and qualitative changes in plasma proteolytic activity, further amplified by prior SARS-CoV-2 infection. The combination of elevated serine protease levels, high-molecular-weight complex formation, and...
This study identified enhanced serine protease activity and altered proteolytic balance in multiple sclerosis patients, especially post-COVID-19, suggesting sustained immune-metabolic disturbances contributing to neuroinflammation and potential markers for post-infection disease monitoring.
The Consistency and Transferability of Economic Evaluations of Disease-Modifying Treatments for Multiple Sclerosis: Analysis of Cost-Effectiveness Assessments from Australia, England, Canada and Scotland - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41131439/
This study highlighted the consistency of the economic evaluation for DMTs within the four agencies. We also identified a particularly strong alignment between NICE and the CDA, as well as...
This study compared cost-effectiveness assessments of disease-modifying therapies for multiple sclerosis across major HTA agencies, revealing consistent ICER trends within agencies and highlighting purchasing power parity as a superior transferability method.
Neuromyelitis Optica Mimicking Multiple Sclerosis: A Case Report and a Comprehensive Review of the Literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41103591/
Neuromyelitis optica spectrum disorder (NMOSD) may mimic other neurological conditions, including multiple sclerosis (MS). We report a 25-year-old woman with hypothyroidism and depression who presented with progressive quadriparesis. Positive aquaporin-4...
A 25-year-old woman diagnosed with aquaporin-4 antibody–positive NMOSD initially mimicked multiple sclerosis, underscoring the need for accurate differential diagnosis and early immunotherapy to improve neurological outcomes.
Sleep disorders and associated factors in multiple sclerosis patients: a cross-sectional study in Iran - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41087957/
Sleep disorders, such as RLS, insomnia, and OSA, are highly prevalent among PwMS in Iran. Physicians should consider additional clinical characteristics, such as EDSS, when managing RLS. Moreover, demographic features,...
Among nearly 800 Iranian patients with multiple sclerosis, insomnia, restless legs syndrome, and obstructive sleep apnea were highly prevalent. Age, gender, and disability scores significantly influenced sleep disorder risk profiles.