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Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review

Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review

Source : https://pubmed.ncbi.nlm.nih.gov/39266777/

Multiple sclerosis (MS) is a demyelinating neurological disorder with a highly heterogeneous clinical presentation and course of progression. Disease-modifying therapies are the only available treatment, as there is no known...

MRI-based machine learning offers promising potential for predicting multiple sclerosis progression, highlighting the need for integrating imaging biomarkers with multimodal patient data to enhance personalized healthcare approaches.

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Diversity and representation within the literature on sexual dysfunction in multiple sclerosis: A systematic review - PubMed

Diversity and representation within the literature on sexual dysfunction in multiple sclerosis: A systematic review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39032400/

Sex, gender identity, sexual orientation, and ethnicity are poorly reported in studies on SD in MS. These variables must be adequately evaluated to ensure research applies across diverse MS patient...

Sex, gender identity, sexual orientation, and ethnicity are inadequately reported in studies on sexual dysfunction in multiple sclerosis, hindering the applicability of findings across diverse patient populations.

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Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers - PubMed

Oculomics analysis in multiple sclerosis: Current ophthalmic clinical and imaging biomarkers - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38858520/

Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal damage. Early recognition and treatment are important for preventing...

Integrating oculomics with existing diagnostic methods offers a promising future for developing non-invasive, cost-effective tools for early detection and diagnosis of Multiple Sclerosis, enhancing patient outcomes.

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The iron maiden: Oligodendroglial metabolic dysfunction in multiple sclerosis and mitochondrial signaling - PubMed

The iron maiden: Oligodendroglial metabolic dysfunction in multiple sclerosis and mitochondrial signaling - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38950685/

Multiple sclerosis (MS) is an autoimmune disease, governed by oligodendrocyte (OL) dystrophy and central nervous system (CNS) demyelination manifesting variable neurological impairments. Mitochondrial mechanisms may drive myelin biogenesis maintaining the...

Thyroid hormone regulation is crucial for oligodendrocyte function and myelin biogenesis; dysregulation in multiple sclerosis leads to impaired lipid biosynthesis, mitochondrial dysfunction, and neurodegeneration, exacerbating disease progression.

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Diagnostic and Prognostic Innovations in MS

In this video highlighting key takeaways from ECTRIMS 2024, Dr. David A. Hafler, Chairman of the Department of Neurology and Professor of Immunology at Yale School of Medicine, presented advancements in the diagnosis and treatment of Multiple Sclerosis (MS), focusing on genetic biomarkers that predict disease progression. He emphasized the potential of Bruton's Tyrosine Kinase (BTK) inhibitors for treating relapsing-remitting MS, particularly in patients with autoimmune conditions, and discussed the connection between genetic variants and disease progression in the brain and central nervous system. Dr. Hafler also highlighted B-cell suppression as a promising first-line treatment, with evidence supporting the role of the Epstein-Barr virus in triggering immune responses that affect B cells.