How Early Is Early Multiple Sclerosis? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38202221/
The development and further optimization of the diagnostic criteria for multiple sclerosis (MS) emphasize the establishment of an early and accurate diagnosis. So far, numerous studies have revealed the significance...
This review highlights the importance of early diagnosis and treatment of multiple sclerosis, emphasizing biomarkers for identifying high-risk individuals with radiologically isolated syndrome (RIS) who may progress to MS.
Biological aging in multiple sclerosis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37877740/
Multiple sclerosis (MS) is most likely to adopt a progressive clinical course during middle age or beyond, and the number of older adults with MS is steadily increasing. Developing new...
This review highlights the link between biological aging and progressive multiple sclerosis, emphasizing the need for new biomarkers and senotherapies to slow neurological decline by targeting aging-related pathways.
Progressive Encephalomyelopathy in an Older Man: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38386951/
We present a case of subacute onset progressive encephalomyelopathy in a 77-year-old man with symmetric lateral column signal abnormalities on spinal MRI. We discuss the differential and presumptive final diagnosis...
A 77-year-old man presented with subacute progressive encephalomyelopathy and symmetric lateral column signal abnormalities on spinal MRI. The case discusses differential diagnosis, final presumptive diagnosis, and disease immunopathogenesis review.
Thrombotic Microangiopathy after a 15-year Treatment with Interferon Beta-1b in a Patient with Multiple Sclerosis: A Case Report and Review of Literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37661454/
A 54-year-old woman with multiple sclerosis treated with interferon-β (IFN-β)-1b for 15 years presented with sustained hypertension (240/124 mmHg) and retinal bleeding. She had proteinuria, anemia, thrombocytopenia, elevated serum creatinine...
A 54-year-old woman with multiple sclerosis developed thrombotic microangiopathy (TMA) after 15 years of IFN-β-1b treatment, presenting with hypertension, retinal bleeding, proteinuria, anemia, and renal dysfunction. TMA improved after treatment cessation.
Multiple sclerosis and amyotrophic lateral sclerosis: is there an association or a red flag? A case report and literature review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39217293/
The co-occurrence of ALS and MS is extremely rare, but it can be explained by pathogenesis related to neurodegeneration, inflammation, or genetic susceptibility. Rapid progressive motor and bulbar symptoms could...
A 46-year-old female with MS-like symptoms developed rapid progression, bulbar dysfunction, and muscle atrophy. Neurophysiological tests confirmed ALS. Co-occurrence of ALS and MS, though rare, may involve neurodegeneration and inflammation.