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Comparative analysis of plasma proteolytic profiles in multiple sclerosis patients with and without a history of COVID-19 - PubMed

Comparative analysis of plasma proteolytic profiles in multiple sclerosis patients with and without a history of COVID-19 - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41167049/

MS is associated with persistent quantitative and qualitative changes in plasma proteolytic activity, further amplified by prior SARS-CoV-2 infection. The combination of elevated serine protease levels, high-molecular-weight complex formation, and...

This study identified enhanced serine protease activity and altered proteolytic balance in multiple sclerosis patients, especially post-COVID-19, suggesting sustained immune-metabolic disturbances contributing to neuroinflammation and potential markers for post-infection disease monitoring.

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1mo
The Consistency and Transferability of Economic Evaluations of Disease-Modifying Treatments for Multiple Sclerosis: Analysis of Cost-Effectiveness Assessments from Australia, England, Canada and Scotland - PubMed

The Consistency and Transferability of Economic Evaluations of Disease-Modifying Treatments for Multiple Sclerosis: Analysis of Cost-Effectiveness Assessments from Australia, England, Canada and Scotland - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41131439/

This study highlighted the consistency of the economic evaluation for DMTs within the four agencies. We also identified a particularly strong alignment between NICE and the CDA, as well as...

This study compared cost-effectiveness assessments of disease-modifying therapies for multiple sclerosis across major HTA agencies, revealing consistent ICER trends within agencies and highlighting purchasing power parity as a superior transferability method.

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1mo
Neuromyelitis Optica Mimicking Multiple Sclerosis: A Case Report and a Comprehensive Review of the Literature - PubMed

Neuromyelitis Optica Mimicking Multiple Sclerosis: A Case Report and a Comprehensive Review of the Literature - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41103591/

Neuromyelitis optica spectrum disorder (NMOSD) may mimic other neurological conditions, including multiple sclerosis (MS). We report a 25-year-old woman with hypothyroidism and depression who presented with progressive quadriparesis. Positive aquaporin-4...

A 25-year-old woman diagnosed with aquaporin-4 antibody–positive NMOSD initially mimicked multiple sclerosis, underscoring the need for accurate differential diagnosis and early immunotherapy to improve neurological outcomes.

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1mo
Sleep disorders and associated factors in multiple sclerosis patients: a cross-sectional study in Iran - PubMed

Sleep disorders and associated factors in multiple sclerosis patients: a cross-sectional study in Iran - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/41087957/

Sleep disorders, such as RLS, insomnia, and OSA, are highly prevalent among PwMS in Iran. Physicians should consider additional clinical characteristics, such as EDSS, when managing RLS. Moreover, demographic features,...

Among nearly 800 Iranian patients with multiple sclerosis, insomnia, restless legs syndrome, and obstructive sleep apnea were highly prevalent. Age, gender, and disability scores significantly influenced sleep disorder risk profiles.

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1mo
Psych Congress 2025: Moving beyond symptom control toward holistic psychiatric care

At Psych Congress 2025, thought leaders emphasized a shift in psychiatric care from symptom control toward enhancing patient functioning and quality of life. Dr. Julie Carbray, Clinical Professor of Psychiatry and Nursing at the University of Illinois Chicago, discussed incorporating sleep science and digital therapeutics into treatment strategies for depression and ADHD to support whole-person care. Dr. Christoph Correll, Professor of Psychiatry and Molecular Medicine at Zucker School of Medicine, presented data on long-acting subcutaneous therapy for schizophrenia, emphasizing its sustained clinical impact. Collectively, these insights highlight psychiatry’s evolving commitment to evidence-based, patient-centered approaches.