Adenosine A₂A receptor as a dual-acting molecular switch: Glial morphological changes and neurovascular tissue remodeling in neuroinflammation and neurodegeneration - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41690071/
Neuroinflammation appears in a variety of neurological disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis. The adenosine A₂A receptor (A₂AR), a Gs protein-coupled...
Review examines adenosine A₂A receptor signaling in neuroinflammation, highlighting context-dependent glial activation, blood-brain barrier modulation, and therapeutic targeting strategies relevant to multiple sclerosis and other neurodegenerative disorders.
Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41645884/
Multiple sclerosis is a chronic inflammatory and demyelinating disease that primarily affects young adults. Active demyelination and neurodegeneration have been associated with early microglial and astroglial activation. While reactive microglia...
Experimental in vitro study shows CSF-1R–mediated microglial depletion followed by repopulation yields less activated microglia that support oligodendroglial survival and differentiation, despite limited debris clearance, highlighting remyelination-relevant microglial modulation strategies.
Patient Experiences with Relapsing-Remitting and Primary Progressive Multiple Sclerosis: Development of a Conceptual Model to Inform Clinical Outcome Assessment Evaluation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41622359/
This study highlights the multidimensional burden of living with RRMS and PPMS. A provisional conceptual model was developed, harmonizing the TLR and interview findings. This conceptual model may be used...
Qualitative research combining literature review and patient interviews to develop a conceptual model capturing symptoms, functional limitations, and quality-of-life impacts in relapsing-remitting and primary progressive multiple sclerosis across disease courses.
Neurofilament light chain as a surrogate candidate for disease activity in multiple sclerosis (LUMINOUS)-A meta-regression of randomized controlled trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41574448/
In MS, treatment effects on s/pNfL are moderately associated with therapeutic effects on ARR, MRI new/enlarging T2 lesions, and CDW, whereas no consistent association was observed with PBVC.
Meta-regression of randomized trials shows treatment-related reductions in serum or plasma neurofilament light chain moderately correlate with relapse rate, disability worsening, and MRI lesion activity, supporting its role as a disease activity biomarker.
Violence and multiple sclerosis: Towards an evidence-informed call to action in neurology - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/41527696/
Violence is a global health concern with profound physical, psychological and social consequences. People with multiple sclerosis (MS) may experience sustained risk due to the intersection of chronic illness, disability,...
Review synthesizes emerging evidence on violence affecting people with multiple sclerosis, highlighting unmet research needs and advocating trauma-informed, case-finding approaches to improve recognition, response, and integration of violence-informed care into neurology services.