Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis - Journal of Neuroinflammation
Source : https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02691-3
Acetylcholine receptor (AChR) myasthenia gravis (MG) is a chronic autoimmune disease characterized by muscle weakness. The AChR+ autoantibodies are produced by B-cells located in thymic ectopic germinal centers (eGC). No...
Conclusions: Altogether, these data suggest that a therapy targeting IL-23p19 may promote significant clinical ameliorations in AChR MG disease due to concomitant beneficial effects on the thymus and skeletal muscle defects.
Analysis of influencing factors of perioperative myasthenic crisis in 387 myasthenia gravis patients without thymoma in a single center - Journal of Cardiothoracic Surgery
Source : https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-023-02136-1
Objective To study the influencing factors of myasthenic crisis in non-thymoma myasthenia gravis (MG) patients during perioperative period. Methods We retrospectively analyzed a total of 387 non-thymoma MG patients who...
Conclusions: Patients with poor Osserman classification, history of myasthenic crisis before surgery, larger preoperative dosage of pyridostigmine, and higher ASA scores should be highly alert to the occurrence of postoperative myasthenic crisis.
JAK2 inhibitor ameliorates the progression of experimental autoimmune myasthenia gravis and balances Th17/Treg cells via regulating the JAK2/STAT3-AKT/mTOR signaling pathway
Source : https://www.sciencedirect.com/science/article/pii/S1567576923000164?via=ihub
An imbalance in Th17/regulatory T (Treg) cells is the major pathogenic mechanism underlying myasthenia gravis (MG). JAK2 inhibitors selectively inhibi...
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Conclusions: JAK2 inhibitors could be a therapeutic candidate for MG treatment.
Perspectives from the periphery of Paediatrics
Source : https://www.frontiersin.org/articles/10.3389/fpsyg.2022.1044692/full
of the differences between child and adult health. According to the NHS 1 , paediatric care is defined as "covering children from birth to the age of 16" clearly outlining,...
Conclusions: The gap between paediatric and adult care is, undeniably, colossal. Without a doubt, navigating the journey between these vastly different domains of care can prove extremely challenging for all involved; whether this be patients, parents and carers, or clinicians themselves. However, having personally traversed this avenue filled...
Development and Application of a Cell-Based Assay for LRP4 Antibody Associated With Myasthenia Gravis
Source : https://thejcn.com/DOIx.php?id=10.3988/jcn.2023.19.1.60
Development and Application of a Cell-Based Assay for LRP4 Antibody Associated With Myasthenia Gravis Hye Yoon Chung Min Ju Kim Seung Woo Kim Jeeyoung Oh Ha Young Shin a ,...
Conclusions: A CBA for detecting LRP4-Ab associated with MG has been developed, and was used to find LRP4-Ab in the sera of patients with MG.