Development and Application of a Cell-Based Assay for LRP4 Antibody Associated With Myasthenia Gravis
Source : https://thejcn.com/DOIx.php?id=10.3988/jcn.2023.19.1.60
Development and Application of a Cell-Based Assay for LRP4 Antibody Associated With Myasthenia Gravis Hye Yoon Chung Min Ju Kim Seung Woo Kim Jeeyoung Oh Ha Young Shin a ,...
Conclusions: A CBA for detecting LRP4-Ab associated with MG has been developed, and was used to find LRP4-Ab in the sera of patients with MG.
Efgartigimod improved health-related quality of life in generalized myasthenia gravis: results from a randomized, double-blind, placebo-controlled, phase 3 study (ADAPT) - Journal of Neurology
Source : https://link.springer.com/article/10.1007/s00415-022-11517-w
There are substantial disease and health-related quality-of-life (HRQoL) burdens for many patients with myasthenia gravis (MG), especially for those whose disease symptoms are not well controlled. HRQoL measures such as...
Conclusions: Treatment with efgartigimod resulted in significant and rapid HRQoL improvements for up to 8 weeks after the first infusion in TC 1 and TC 2.
Minimal symptom expression achievement over time in generalized myasthenia gravis - Acta Neurologica Belgica
Source : https://link.springer.com/article/10.1007/s13760-022-02162-1
Objectives Minimal symptom expression (MSE), defined as myasthenia gravis (MG) activities of daily living profile (MGADL) score 0 or 1, has been recently used as an indicator of treatment goal...
Conclusions: From the early phases of immunotherapy, MSE is a good marker of therapeutic goal in patients with generalized MG.
Acetylcholine receptor binding antibody-associated myasthenia gravis, myocarditis, and rhabdomyolysis induced by tislelizumab in a patient with colon cancer: A case report and literature review
Source : https://www.frontiersin.org/articles/10.3389/fonc.2022.1053370/full
Despite the intriguing therapeutic prospects offered by immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs) become an increasingly important safety issue. Herein, we report a patient with locally advanced colorectal...
Conclusions: This case illustrates the severe toxicity caused by ICIs, highlighting the importance of early prevention, early diagnosis, and appropriate management of irAEs. Multidisciplinary discussions should be held to improve the prognosis of patients.
Pneumonia in myasthenia gravis: Microbial etiology and clinical management
Source : https://www.frontiersin.org/articles/10.3389/fcimb.2022.1016728/full
IntroductionPatients with myasthenia gravis (MG) are prone to the development of pneumonia due to the long-term immunotherapies they receive and a tendency for aspiration. Pneumonia remains a risk factor for...
Conclusions: Our identification of the microbial etiology of pneumonia in MG patients may provide future perspectives on accurate antibiotic options and enable early interventions when risk factors are present.