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Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology - Acta Neuropathologica

Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology - Acta Neuropathologica

Source : https://link.springer.com/article/10.1007/s00401-023-02603-y

Serum autoantibodies targeting the nicotinic acetylcholine receptor (AChR) in patients with autoimmune myasthenia gravis (MG) can mediate pathology via three distinct molecular mechanisms: complement activation, receptor blockade, and antigenic modulation....

Conclusions/Relevance: These findings provide new insight into the immunopathology of MG, demonstrating that single autoreactive clones can efficiently mediate multiple modes of pathology. Current therapeutic approaches targeting only one autoantibody-mediated pathogenic mechanism may be evaded by autoantibodies with multifaceted capacity.

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Myasthenia-like paraneoplastic syndrome with multiple... : Medicine

Myasthenia-like paraneoplastic syndrome with multiple... : Medicine

Source : https://journals.lww.com/md-journal/Fulltext/2023/05190/Myasthenia_like_paraneoplastic_syndrome_with.52.aspx

ation with primary lung cancer remains unknown. Patient concerns: A 55-year-old female presented with slurred speech, weakness in chewing, sporadic difficulty in swallowing, and weakness in both lower limbs for...

Lessons: Although it is unclear why MG coexists with lung cancer, it is probable that MG is a paraneoplastic condition. Cerebrospinal fluid testing should be carried out along with electrophysiological, serological, and pharmacological procedures pertinent to the diagnosis of MG to thoroughly examine if people simultaneously experience...

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Myasthenic crisis as an initial presentation of myasthenia gravis in an 81-year-old following endoscopic myotomy for Zenker's diverticulum

Myasthenic crisis as an initial presentation of myasthenia gravis in an 81-year-old following endoscopic myotomy for Zenker's diverticulum

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10269386/

In this article, we present the case of a patient with previously undiagnosed myasthenia gravis who underwent an endoscopic procedure for Zenker's diverticulum. The patient was readmitted due to ongoing...

Conclusions/Relevance: This case demonstrates that myasthenia gravis, although rare, can occur in elderly patients and present with other sequelae that may mask the underlying diagnosis.

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Dropped Head Syndrome As a Presenting Sign of Different Diseases: Report of Three Cases - PubMed

Dropped Head Syndrome As a Presenting Sign of Different Diseases: Report of Three Cases - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37287555/

Dropped head is an abnormal forward flexion of the cervical spine. Patients can straighten their heads with support. This condition, which is seen as neck extensor muscle weakness, is defined...

Relevance: We aimed to present 3 different cases with a diagnosis of myasthenia gravis, inflammatory myopathy, and amyotrophic lateral sclerosis presenting with dropped head.

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New-Onset Myasthenia Gravis Mimics Spinal Cord Injury After Zenker's Diverticulum Repair - PubMed

New-Onset Myasthenia Gravis Mimics Spinal Cord Injury After Zenker's Diverticulum Repair - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/37305099/

New-Onset Myasthenia Gravis Mimics Spinal Cord Injury After Zenker's Diverticulum Repair

Conclusions/Relevance: This report presents a rare case of new-onset MG diagnosed in the immediate postoperative period after a Zenker's repair. It demonstrates that intraoperative events can unmask MG during the subclinical stage of the disease, lead physicians to other diagnostic considerations because of the general unfamiliarity with this...