gMG Connect
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2yr
TLR4-MyD88-NF-κB Signaling Imbalances Th17 and Treg Cells in Thymoma With Myasthenia Gravis

TLR4-MyD88-NF-κB Signaling Imbalances Th17 and Treg Cells in Thymoma With Myasthenia Gravis

Source : https://pubmed.ncbi.nlm.nih.gov/37975358/

TLR4 is stimulated in thymoma, causing an increase of Th17 cells and a decrease of Treg cells, namely an imbalance of Th17/Treg cells, resulting in MG.

TLR4, MyD88, and NF-κB were expressed more in MG thymoma compared with simple thymoma.

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2yr
Causal Relationship Between Gut Microbiota and Myasthenia Gravis: a Bidirectional Mendelian Randomization Study

Causal Relationship Between Gut Microbiota and Myasthenia Gravis: a Bidirectional Mendelian Randomization Study

Source : https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-023-01163-8

Observational studies have demonstrated an association between gut microbiota and myasthenia gravis; however, the causal relationship between the two still lacks clarity. Our goals are to ascertain the existence of...

The results demonstrated that the families Clostridiaceae, Defluviitaleaceae, and Enterobacteriaceae were negatively correlated with risk of MG, whereas the genus Lachnoclostridium was positively correlated with risk of MG.

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2yr
The Burden Patients With Myasthenia Gravis Experience in Terms of Breathing, Fatigue, Sleep, Mental Health, Discomfort and Usual Activities in Comparison to the General Population

The Burden Patients With Myasthenia Gravis Experience in Terms of Breathing, Fatigue, Sleep, Mental Health, Discomfort and Usual Activities in Comparison to the General Population

Source : https://link.springer.com/article/10.1007/s12325-023-02704-w

Myasthenia gravis (MG) is a rare neuromuscular disorder marked by a variable combination of weakness of eye, bulbar, respiratory, axial, and limb muscles. This study compared the experience of people...

Patients with MG experienced significantly more mental health issues, pain, and difficulties in performing usual activities versus the general population.

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2yr
Summary of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) 2023 Annual Meeting

The annual meeting of the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) brought together neurologists, physiatrists, researchers, and advanced practice providers to learn more about the latest advances in diagnosing and treating neuromuscular disorders. The four-day meeting took place at the JW Marriott Phoenix Desert Ridge Resort & Spa.

Above, please find our post-conference wrap-up report.

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2yr
Myasthenia Gravis and Five Autoimmune Diseases: a Bidirectional Mendelian Randomization Study

Myasthenia Gravis and Five Autoimmune Diseases: a Bidirectional Mendelian Randomization Study

Source : https://link.springer.com/article/10.1007/s10072-023-07163-3

The association between myasthenia gravis (MG) and other autoimmune diseases is well established. In this study, we aimed to investigate the causal effects between MG and five other autoimmune diseases,...

When MG was treated as the exposure, MR evidence suggested a causal relationship between MG and T1DM, SLE, AITD (both hypothyroidism and hyperthyroidism), and MS (excluding RA).