gMG Connect
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B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases

B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases

Source : https://pubmed.ncbi.nlm.nih.gov/38760099/

The approval of monoclonal antibodies, such as ocrelizumab and ofatumumab, which target CD20, and inebilizumab, which targets CD19, for the treatment of various neuroimmunological diseases reflects progress in the understanding...

CAR T cell therapy is showing promise as a treatment for gMG, potentially offering extended disease-free survival. While initial data are encouraging, safety concerns, especially neurotoxicity, remain significant. Ongoing studies are crucial to confirm the efficacy and safety of this innovative approach, aiming to revolutionize gMG treatment...

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Efgartigimod and Ravulizumab for Treating Acetylcholine Receptor Auto-antibody-Positive (AChR-Ab+) Generalized Myasthenia Gravis: Indirect Treatment Comparison

Efgartigimod and Ravulizumab for Treating Acetylcholine Receptor Auto-antibody-Positive (AChR-Ab+) Generalized Myasthenia Gravis: Indirect Treatment Comparison

Source : https://pubmed.ncbi.nlm.nih.gov/38642198/

Efgartigimod may provide a faster and greater improvement over 26 weeks in quality of life than ravulizumab in adults with AChR-Ab+ gMG. Efgartigimod showed faster improvements in MG-ADL and QMG...

Efgartigimod may provide a faster and greater improvement over 26 weeks in quality of life than ravulizumab in adults with AChR-Ab+ gMG. Efgartigimod showed faster improvements in MG-ADL and QMG than ravulizumab.

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Advancements and prospects of novel biologicals for myasthenia gravis: toward personalized treatment based on autoantibody specificities

Advancements and prospects of novel biologicals for myasthenia gravis: toward personalized treatment based on autoantibody specificities

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177092/

Myasthenia gravis (MG) is an antibody-mediated autoimmune disease with a prevalence of 150-250 cases per million individuals. Autoantibodies include long-lived antibodies against the acetylcholine receptor (AChR), mainly of the IgG1...

Early conventional immunosuppressive drugs were effective, but a series of adverse events brought great physical and psychological burdens to patients, especially those who have been using them for a long-term period. In recent years, it is not only myasthenia gravis but also many neuroimmune diseases that have gone beyond the conventional...

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Loco-Regional Anesthesia for Pain Management in Robotic Thoracic Surgery

Loco-Regional Anesthesia for Pain Management in Robotic Thoracic Surgery

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11172511/

Robotic thoracic surgery is a prominent minimally invasive approach for the treatment of various thoracic diseases. While this technique offers numerous benefits including reduced blood loss, shorter hospital stays, and...

The future of loco-regional anesthesia in robotic thoracic surgery is promising, with advancements in technology and precision medicine expected to enhance patient outcomes. As minimally invasive surgical approaches continue to gain popularity, there is a growing need for equally minimally invasive anesthetic techniques that provide effective...

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Coexistence of myasthenia gravis and lichen planus: A case report and systematic review of related case reports from 1971 to 2024

Coexistence of myasthenia gravis and lichen planus: A case report and systematic review of related case reports from 1971 to 2024

Source : https://pubmed.ncbi.nlm.nih.gov/38883218/

Myasthenia gravis (MG) is an uncommon autoimmune disease, resulting in fatigable muscle weakness in the ocular, bulbar, and respiratory muscles, as well as muscles of the extremities. Lichen planus (LP)...

While the exact pathogenesis of MG, LP, and thymoma co‐occurrence remains elusive, it suggests the possibility of a shared autoimmune mechanism. Various theories have been suggested to explain the association between thymoma and autoimmune disorders or paraneoplastic syndromes due to T lymphocyte dysfunction, genetic predisposition, and...