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Refocusing generalized myasthenia gravis: Patient burden, disease profiles, and the role of evolving therapy - PubMed

Refocusing generalized myasthenia gravis: Patient burden, disease profiles, and the role of evolving therapy - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38117543/

gMG has a physical, mental, and social impact, resulting in a considerable burden of disease and substantially decreased QoL, despite standard treatments. The availability of novel, targeted treatments that influence...

Generalized myasthenia gravis (gMG) presents management challenges, but new treatments, consensus definitions, standardized assessments, and biomarkers offer opportunities to optimize care, improve quality of life, and reduce disease burden.

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Safety and Efficacy of Nipocalimab in Patients With Generalized Myasthenia Gravis: Results From the Randomized Phase 2 Vivacity-MG Study - PubMed

Safety and Efficacy of Nipocalimab in Patients With Generalized Myasthenia Gravis: Results From the Randomized Phase 2 Vivacity-MG Study - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38165333/

This study provides Class I evidence that for patients with gMG, nipocalimab was well-tolerated, and it did not significantly improve MG-ADL at any individual dose but demonstrated a significant dose...

A phase 2 study of IV nipocalimab in generalized myasthenia gravis showed it was safe, well-tolerated, and demonstrated a significant dose-dependent reduction in Myasthenia Gravis-Activities of Daily Living scores.

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Comparative Analysis of Intravenous Immunoglobulins (IVIg) vs Plasmapheresis (PLEX) in the Management of Myasthenic Crisis - PubMed

Comparative Analysis of Intravenous Immunoglobulins (IVIg) vs Plasmapheresis (PLEX) in the Management of Myasthenic Crisis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39376877/

Myasthenia gravis (MG) is an autoimmune disorder affecting postsynaptic membranes in neuromuscular junctions, presenting as fatigable muscle weakness. Myasthenic crisis is a life-threatening complication characterized by severe respiratory insufficiency necessitating...

This article compares IVIg and PLEX for myasthenic crisis management, emphasizing individualized treatment based on patient factors, resources, and preferences, while advocating further research for definitive guidelines and improved outcomes.

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1yr
Summary of the best evidence for the prevention and management of myasthenic crisis after thymectomy - PubMed

Summary of the best evidence for the prevention and management of myasthenic crisis after thymectomy - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38720682/

This study summarized the best evidence on the prevention and management of postoperative MC and provided to clinical staffs evidence-based clinical approaches to help reduce the incidence of this complication.

This study reviewed 12 high-quality sources, summarizing 39 evidence-based strategies to prevent and manage postoperative myasthenic crisis, offering a comprehensive clinical framework to reduce its incidence in myasthenia gravis patients.

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1yr

Did you know? Stanford University made a groundbreaking advance with COSMOS, a bifocal microscopy technique that captures real-time movies of neural activity across the entire cerebral cortex of a mouse brain. By filming from three angles and computationally extracting the signals, they created a live video showing the brain's macroscopic activity, revealing the dynamic "electrical storm" of brain function in action.

How could this new method of visualizing brain activity transform our understanding of neural processes and neurological disorders?

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How could this new method of visualizing brain activity transform our understanding of neural processes and neurological disorders?