Metformin Inhibits the Pathogenic Functions of AChR-specific B and Th17 Cells by Targeting miR-146a
Source : https://www.sciencedirect.com/science/article/abs/pii/S0165247822001195?via=ihub
We established a classical animal model of myasthenia gravis as the experimental basis for the study of miR-146a. * We found that miR-146a expressed differently in thymus, lymph nodes and...
Conclusion/Relevance: We found that miR-146a expressed differently in thymus, lymph nodes and spleen of rat model, and the expression of mR-146a in disease specific T and B cells was also in a cell dependent manner. Pathological character of disease specific Th17 and B cells could be reversed by the metformin alternation of miR-146a levels in...
Pyridostigmine-induced coronary artery spasm in early-onset myasthenia gravis: a case presentation and review of the literature
Source : https://casereports.bmj.com/content/15/9/e249819
We present a case of pyridostigmine-induced coronary artery spasm in a woman with early-onset myasthenia gravis (MG) who suffered from acute chest discomfort a few days after pyridostigmine dose up-titration....
Relevance: We present a case of pyridostigmine-induced coronary artery spasm in a woman with early-onset myasthenia gravis (MG) who suffered from acute chest discomfort a few days after pyridostigmine dose up-titration. Twelve-lead ECG demonstrated ST-segment elevation in inferior limb leads together with sinus arrest.